Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.

by: O Elemento, S Tavazoie

Genome Biol, Vol. 6, No. 2. (2005)

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Abstract

We describe a powerful new approach for discovering globally conserved regulatory elements between two genomes. The method is fast, simple and comprehensive, without requiring alignments. Its application to pairs of yeasts, worms, flies and mammals yields a large number of known and novel putative regulatory elements. Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances.

@article{citeulike:1085571, abstract = {We describe a powerful new approach for discovering globally conserved regulatory elements between two genomes. The method is fast, simple and comprehensive, without requiring alignments. Its application to pairs of yeasts, worms, flies and mammals yields a large number of known and novel putative regulatory elements. Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances.}, address = {Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. elemento@princeton.edu}, author = {Elemento, O. and Tavazoie, S. }, citeulike-article-id = {1085571}, doi = {10.1186/gb-2005-6-2-r18}, issn = {1465-6914}, journal = {Genome Biol}, keywords = {comprative, genomic}, number = {2}, posted-at = {2008-05-09 01:08:22}, priority = {2}, title = {Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.}, url = {http://dx.doi.org/10.1186/gb-2005-6-2-r18}, volume = {6}, year = {2005} }

RIS record

TY - JOUR ID - citeulike:1085571 L3 - citeulike-article-id:1085571 TI - Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach. JF - Genome Biol VL - 6 IS - 2 AD - Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA. elemento@princeton.edu SN - 1465-6914 N2 - We describe a powerful new approach for discovering globally conserved regulatory elements between two genomes. The method is fast, simple and comprehensive, without requiring alignments. Its application to pairs of yeasts, worms, flies and mammals yields a large number of known and novel putative regulatory elements. Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances. KW - comprative KW - genomic AU - Elemento, O AU - Tavazoie, S PY - 2005/// UR - http://dx.doi.org/10.1186/gb-2005-6-2-r18 ER -

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