Hippocampal Sharp Waves and Reactivation during Awake States Depend on Repeated Sequential Experience

@article{citeulike:968547, abstract = {Hippocampal firing patterns during behavior are reactivated during rest and subsequent slow-wave sleep. These reactivations occur during transient local field potential (LFP) events, termed sharp waves. Theories of hippocampal processing suggest that sharp waves arise from strengthened plasticity, and that the strengthened plasticity depends on repeated cofiring of pyramidal cells. We tested these predictions by recording neural ensembles and LFPs from rats running tasks requiring different levels of behavioral repetition. The number of sharp waves emitted increased during sessions with more regular behaviors. Reactivation became more similar to behavioral firing patterns across the session. This enhanced reactivation also depended on the regularity of the behavior. Additional studies in CA3 and CA1 found that the number of sharp waves emitted also increased in CA3 recordings as well as CA1, but that the time courses were different between the two structures. 10.1523/JNEUROSCI.4118-06.2006}, author = {Jackson, Jadin C. and Johnson, Adam and Redish, David A. }, citeulike-article-id = {968547}, comment = {reactivation during spw-r is correlated with \# of repetitions of an action}, doi = {10.1523/JNEUROSCI.4118}, journal = {J. Neurosci.}, keywords = {consolidation, hippocampus, memory, spw-r}, month = {November}, number = {48}, pages = {12415--12426}, posted-at = {2006-11-30 11:09:54}, priority = {2}, title = {Hippocampal Sharp Waves and Reactivation during Awake States Depend on Repeated Sequential Experience}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4118}, volume = {26}, year = {2006} }

TY - JOUR ID - citeulike:968547 L3 - citeulike-article-id:968547 TI - Hippocampal Sharp Waves and Reactivation during Awake States Depend on Repeated Sequential Experience JF - J. Neurosci. VL - 26 IS - 48 SP - 12415 EP - 12426 N2 - Hippocampal firing patterns during behavior are reactivated during rest and subsequent slow-wave sleep. These reactivations occur during transient local field potential (LFP) events, termed sharp waves. Theories of hippocampal processing suggest that sharp waves arise from strengthened plasticity, and that the strengthened plasticity depends on repeated cofiring of pyramidal cells. We tested these predictions by recording neural ensembles and LFPs from rats running tasks requiring different levels of behavioral repetition. The number of sharp waves emitted increased during sessions with more regular behaviors. Reactivation became more similar to behavioral firing patterns across the session. This enhanced reactivation also depended on the regularity of the behavior. Additional studies in CA3 and CA1 found that the number of sharp waves emitted also increased in CA3 recordings as well as CA1, but that the time courses were different between the two structures. 10.1523/JNEUROSCI.4118-06.2006 KW - consolidation KW - hippocampus KW - memory KW - spw-r N1 - reactivation during spw-r is correlated with # of repetitions of an action AU - Jackson, Jadin AU - Johnson, Adam AU - Redish, David PY - 2006/11/29/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4118 ER -