Altered Behavioral Responses to Noxious Stimuli and Fear in Glutamate Receptor 5 (GluR5)- or GluR6-Deficient Mice

@article{citeulike:903713, abstract = {Different kainate receptor (KAR) subtypes contribute to the regulation of both excitatory and inhibitory transmission. However, no study has reported a role for KAR subtypes in behavioral responses to persistent pain and fear memory. Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 (GluR5) but not GluR6 subunits. In classic fear-memory tests, mice lacking GluR6 but not GluR5 showed a significant reduction in fear memory when measured 3, 7, or 14 d after training. Additionally, synaptic potentiation was significantly reduced in the lateral amygdala of GluR6 but not GluR5 knock-out mice. Our findings provide evidence that distinct KAR subtypes contribute to chemical/inflammatory pain and fear memory. Selectively targeting different KAR subtypes may provide a useful strategy for treating persistent pain and fear-related mental disorders. 10.1523/JNEUROSCI.4059-04.2005}, author = {Ko, Shanelle and Zhao, Ming-Gao and Toyoda, Hiroki and Qiu, Chang-Shen and Zhuo, Min }, citeulike-article-id = {903713}, doi = {http://dx.doi.org/10.1523/JNEUROSCI.4059}, journal = {J. Neurosci.}, keywords = {aversive, conditioning, kainate, knockout}, month = {January}, number = {4}, pages = {977--984}, posted-at = {2006-10-18 14:28:32}, priority = {2}, title = {Altered Behavioral Responses to Noxious Stimuli and Fear in Glutamate Receptor 5 (GluR5)- or GluR6-Deficient Mice}, url = {http://dx.doi.org/10.1523/JNEUROSCI.4059}, volume = {25}, year = {2005} }

TY - JOUR ID - citeulike:903713 L3 - citeulike-article-id:903713 TI - Altered Behavioral Responses to Noxious Stimuli and Fear in Glutamate Receptor 5 (GluR5)- or GluR6-Deficient Mice JF - J. Neurosci. VL - 25 IS - 4 SP - 977 EP - 984 N2 - Different kainate receptor (KAR) subtypes contribute to the regulation of both excitatory and inhibitory transmission. However, no study has reported a role for KAR subtypes in behavioral responses to persistent pain and fear memory. Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 (GluR5) but not GluR6 subunits. In classic fear-memory tests, mice lacking GluR6 but not GluR5 showed a significant reduction in fear memory when measured 3, 7, or 14 d after training. Additionally, synaptic potentiation was significantly reduced in the lateral amygdala of GluR6 but not GluR5 knock-out mice. Our findings provide evidence that distinct KAR subtypes contribute to chemical/inflammatory pain and fear memory. Selectively targeting different KAR subtypes may provide a useful strategy for treating persistent pain and fear-related mental disorders. 10.1523/JNEUROSCI.4059-04.2005 KW - aversive KW - conditioning KW - kainate KW - knockout AU - Ko, Shanelle AU - Zhao, Ming-Gao AU - Toyoda, Hiroki AU - Qiu, Chang-Shen AU - Zhuo, Min PY - 2005/01/26/ UR - http://dx.doi.org/10.1523/JNEUROSCI.4059 ER -