The ventral striatum in off-line processing: ensemble reactivation during sleep and modulation by hippocampal ripples.

@article{citeulike:2208709, abstract = {Previously it has been shown that the hippocampus and neocortex can spontaneously reactivate ensemble activity patterns during post-behavioral sleep and rest periods. Here we examined whether such reactivation also occurs in a subcortical structure, the ventral striatum, which receives a direct input from the hippocampal formation and has been implicated in guidance of consummatory and conditioned behaviors. During a reward-searching task on a T-maze, flanked by sleep and rest periods, parallel recordings were made from ventral striatal ensembles while EEG signals were derived from the hippocampus. Statistical measures indicated a significant amount of reactivation in the ventral striatum. In line with hippocampal data, reactivation was especially prominent during post-behavioral slow-wave sleep, but unlike the hippocampus, no decay in pattern recurrence was visible in the ventral striatum across the first 40 min of post-behavioral rest. We next studied the relationship between ensemble firing patterns in ventral striatum and hippocampal ripples-sharp waves, which have been implicated in pattern replay. Firing rates were significantly modulated in close temporal association with hippocampal ripples in 25\% of the units, showing a marked transient enhancement in the average response profile. Strikingly, ripple-modulated neurons in ventral striatum showed a clear reactivation, whereas nonmodulated cells did not. These data suggest, first, the occurrence of pattern replay in a subcortical structure implied in the processing and prediction of reward and, second, a functional linkage between ventral striatal reactivation and a specific type of high-frequency population activity associated with hippocampal replay.}, address = {Graduate School of Neurosciences Amsterdam, University of Amsterdam, Faculty of Science, Swammerdam Institute for Life Sciences, 1090 GB, Amsterdam, The Netherlands. pennartz@science.uva.nl}, author = {Pennartz, C. M. and Lee, E. and Verheul, J. and Lipa, P. and Barnes, C. A. and McNaughton, B. L. }, citeulike-article-id = {2208709}, doi = {10.1523/JNEUROSCI.0575-04.2004}, issn = {1529-2401}, journal = {J Neurosci}, keywords = {hippocampus, replay, spw-r, striatum, ventral\_striatum}, month = {July}, number = {29}, pages = {6446--6456}, posted-at = {2008-02-22 11:02:58}, priority = {2}, title = {The ventral striatum in off-line processing: ensemble reactivation during sleep and modulation by hippocampal ripples.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.0575-04.2004}, volume = {24}, year = {2004} }

TY - JOUR ID - citeulike:2208709 L3 - citeulike-article-id:2208709 TI - The ventral striatum in off-line processing: ensemble reactivation during sleep and modulation by hippocampal ripples. JF - J Neurosci VL - 24 IS - 29 SP - 6446 EP - 6456 AD - Graduate School of Neurosciences Amsterdam, University of Amsterdam, Faculty of Science, Swammerdam Institute for Life Sciences, 1090 GB, Amsterdam, The Netherlands. pennartz@science.uva.nl SN - 1529-2401 N2 - Previously it has been shown that the hippocampus and neocortex can spontaneously reactivate ensemble activity patterns during post-behavioral sleep and rest periods. Here we examined whether such reactivation also occurs in a subcortical structure, the ventral striatum, which receives a direct input from the hippocampal formation and has been implicated in guidance of consummatory and conditioned behaviors. During a reward-searching task on a T-maze, flanked by sleep and rest periods, parallel recordings were made from ventral striatal ensembles while EEG signals were derived from the hippocampus. Statistical measures indicated a significant amount of reactivation in the ventral striatum. In line with hippocampal data, reactivation was especially prominent during post-behavioral slow-wave sleep, but unlike the hippocampus, no decay in pattern recurrence was visible in the ventral striatum across the first 40 min of post-behavioral rest. We next studied the relationship between ensemble firing patterns in ventral striatum and hippocampal ripples-sharp waves, which have been implicated in pattern replay. Firing rates were significantly modulated in close temporal association with hippocampal ripples in 25% of the units, showing a marked transient enhancement in the average response profile. Strikingly, ripple-modulated neurons in ventral striatum showed a clear reactivation, whereas nonmodulated cells did not. These data suggest, first, the occurrence of pattern replay in a subcortical structure implied in the processing and prediction of reward and, second, a functional linkage between ventral striatal reactivation and a specific type of high-frequency population activity associated with hippocampal replay. KW - hippocampus KW - replay KW - spw-r KW - striatum KW - ventral_striatum AU - Pennartz, CM AU - Lee, E AU - Verheul, J AU - Lipa, P AU - Barnes, CA AU - McNaughton, BL PY - 2004/07/21/ UR - http://dx.doi.org/10.1523/JNEUROSCI.0575-04.2004 ER -