Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism

by: Michael J Frank, Johan Samanta, Ahmed A Moustafa, Scott J Sherman

Science (25 October 2007), 1146157.

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Abstract

Deep brain stimulation (DBS) of the subthalamic nucleus dramatically improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. Here we show that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up under high conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients, and were predicted by a single neurocomputational model of the basal ganglia. 10.1126/science.1146157

@article{citeulike:1943924, abstract = {Deep brain stimulation (DBS) of the subthalamic nucleus dramatically improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. Here we show that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up under high conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients, and were predicted by a single neurocomputational model of the basal ganglia. 10.1126/science.1146157}, author = {Frank, Michael J. and Samanta, Johan and Moustafa, Ahmed A. and Sherman, Scott J. }, citeulike-article-id = {1943924}, doi = {10.1126/science.1146157}, journal = {Science}, keywords = {dbs, decision, dopamine, human, parkinson}, month = {October}, pages = {1146157+}, posted-at = {2007-11-23 09:37:11}, priority = {2}, title = {Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism}, url = {http://dx.doi.org/10.1126/science.1146157}, year = {2007} }

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TY - JOUR ID - citeulike:1943924 L3 - citeulike-article-id:1943924 TI - Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism JF - Science SP - 1146157 N2 - Deep brain stimulation (DBS) of the subthalamic nucleus dramatically improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. Here we show that DBS selectively interferes with the normal ability to slow down when faced with decision conflict. While on DBS, patients actually sped up under high conflict conditions. This form of impulsivity was not affected by dopaminergic medication status. Instead, medication impaired patients' ability to learn from negative decision outcomes. These findings implicate independent mechanisms leading to impulsivity in treated Parkinson's patients, and were predicted by a single neurocomputational model of the basal ganglia. 10.1126/science.1146157 KW - dbs KW - decision KW - dopamine KW - human KW - parkinson AU - Frank, Michael AU - Samanta, Johan AU - Moustafa, Ahmed AU - Sherman, Scott PY - 2007/10/25/ UR - http://dx.doi.org/10.1126/science.1146157 ER -

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