Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning

@article{citeulike:1810038, abstract = {What are the genetic and neural components that support adaptive learning from positive and negative outcomes? Here, we show with genetic analyses that three independent dopaminergic mechanisms contribute to reward and avoidance learning in humans. A polymorphism in the DARPP-32 gene, associated with striatal dopamine function, predicted relatively better probabilistic reward learning. Conversely, the C957T polymorphism of the DRD2 gene, associated with striatal D2 receptor function, predicted the degree to which participants learned to avoid choices that had been probabilistically associated with negative outcomes. The Val/Met polymorphism of the COMT gene, associated with prefrontal cortical dopamine function, predicted participants' ability to rapidly adapt behavior on a trial-to-trial basis. These findings support a neurocomputational dissociation between striatal and prefrontal dopaminergic mechanisms in reinforcement learning. Computational maximum likelihood analyses reveal independent gene effects on three reinforcement learning parameters that can explain the observed dissociations. 10.1073/pnas.0706111104}, author = {Frank, Michael J. and Moustafa, Ahmed A. and Haughey, Heather M. and Curran, Tim and Hutchison, Kent E. }, citeulike-article-id = {1810038}, doi = {10.1073/pnas.0706111104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {dopamine, human, pfc, punishment, reinforcement-learning, reward, striatum}, month = {October}, number = {41}, pages = {16311--16316}, posted-at = {2007-10-23 10:47:50}, priority = {2}, title = {Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning}, url = {http://dx.doi.org/10.1073/pnas.0706111104}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:1810038 L3 - citeulike-article-id:1810038 TI - Genetic triple dissociation reveals multiple roles for dopamine in reinforcement learning JF - Proceedings of the National Academy of Sciences VL - 104 IS - 41 SP - 16311 EP - 16316 N2 - What are the genetic and neural components that support adaptive learning from positive and negative outcomes? Here, we show with genetic analyses that three independent dopaminergic mechanisms contribute to reward and avoidance learning in humans. A polymorphism in the DARPP-32 gene, associated with striatal dopamine function, predicted relatively better probabilistic reward learning. Conversely, the C957T polymorphism of the DRD2 gene, associated with striatal D2 receptor function, predicted the degree to which participants learned to avoid choices that had been probabilistically associated with negative outcomes. The Val/Met polymorphism of the COMT gene, associated with prefrontal cortical dopamine function, predicted participants' ability to rapidly adapt behavior on a trial-to-trial basis. These findings support a neurocomputational dissociation between striatal and prefrontal dopaminergic mechanisms in reinforcement learning. Computational maximum likelihood analyses reveal independent gene effects on three reinforcement learning parameters that can explain the observed dissociations. 10.1073/pnas.0706111104 KW - dopamine KW - human KW - pfc KW - punishment KW - reinforcement-learning KW - reward KW - striatum AU - Frank, Michael AU - Moustafa, Ahmed AU - Haughey, Heather AU - Curran, Tim AU - Hutchison, Kent PY - 2007/10/09/ UR - http://dx.doi.org/10.1073/pnas.0706111104 ER -