Surround inhibition among projection neurons is weak or nonexistent in the rat neostriatum.

@article{citeulike:1571301, abstract = {1. Antidromic activation of striatal spiny projection neurons by substantia nigra stimulation in vivo did not evoke inhibitory postsynaptic potentials (IPSPs) in the antidromically activated neurons, or in neighboring spiny neurons. 2. More generalized activation of projection cells by stimulation of the efferent pathway in slices did not evoke IPSPs in spiny neurons. Inhibitory mechanisms were operative in these slices, as indicated by the presence of an IPSP component in the orthodromic response to local stimulation. 3. Dual intracellular recordings, obtained from cells located within 50-200 microns of each other in striatal slices also failed to demonstrate any inhibition among striatal spiny cells. Spikes triggered in one spiny neuron by current injection failed to produce any postsynaptic potential in nearby spiny cells at resting or depolarized membrane potentials. Excitatory postsynaptic potentials (EPSPs) evoked by electrical stimulation of the cortex were not affected by spiking of neighboring cells. 4. It is impossible to rule out the presence of inhibition among striatal spiny neurons in all circumstances. However, the absence of demonstrable IPSPs in these experiments argue against the common view that mutual inhibition among spiny neurons is a central organizing principle of striatal function.}, address = {Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163.}, author = {Jaeger, D. and Kita, H. and Wilson, C. J. }, citeulike-article-id = {1571301}, comment = {no surround inhibition between msns}, issn = {0022-3077}, journal = {J Neurophysiol}, keywords = {lateral-inhibition, msn, physiology, striatum}, month = {November}, number = {5}, pages = {2555--2558}, posted-at = {2007-08-17 09:40:08}, priority = {2}, title = {Surround inhibition among projection neurons is weak or nonexistent in the rat neostriatum.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7884483}, volume = {72}, year = {1994} }

TY - JOUR ID - citeulike:1571301 L3 - citeulike-article-id:1571301 TI - Surround inhibition among projection neurons is weak or nonexistent in the rat neostriatum. JF - J Neurophysiol VL - 72 IS - 5 SP - 2555 EP - 2558 AD - Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163. SN - 0022-3077 N2 - 1. Antidromic activation of striatal spiny projection neurons by substantia nigra stimulation in vivo did not evoke inhibitory postsynaptic potentials (IPSPs) in the antidromically activated neurons, or in neighboring spiny neurons. 2. More generalized activation of projection cells by stimulation of the efferent pathway in slices did not evoke IPSPs in spiny neurons. Inhibitory mechanisms were operative in these slices, as indicated by the presence of an IPSP component in the orthodromic response to local stimulation. 3. Dual intracellular recordings, obtained from cells located within 50-200 microns of each other in striatal slices also failed to demonstrate any inhibition among striatal spiny cells. Spikes triggered in one spiny neuron by current injection failed to produce any postsynaptic potential in nearby spiny cells at resting or depolarized membrane potentials. Excitatory postsynaptic potentials (EPSPs) evoked by electrical stimulation of the cortex were not affected by spiking of neighboring cells. 4. It is impossible to rule out the presence of inhibition among striatal spiny neurons in all circumstances. However, the absence of demonstrable IPSPs in these experiments argue against the common view that mutual inhibition among spiny neurons is a central organizing principle of striatal function. KW - lateral-inhibition KW - msn KW - physiology KW - striatum N1 - no surround inhibition between msns AU - Jaeger, D AU - Kita, H AU - Wilson, CJ PY - 1994/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/7884483 ER -