Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network

@article{citeulike:1373145, abstract = {Forming distinct representations of multiple contexts, places and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-D-aspartate (NMDA) receptor, NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts. A significant reduction in the context-specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another. These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation. 10.1126/science.1140263}, author = {Mchugh, Thomas J. and Jones, Matthew W. and Quinn, Jennifer J. and Balthasar, Nina and Coppari, Roberto and Elmquist, Joel K. and Lowell, Bradford B. and Fanselow, Michael S. and Wilson, Matthew A. and Tonegawa, Susumu }, citeulike-article-id = {1373145}, doi = {10.1126/science.1140263}, journal = {Science}, keywords = {dentate, extracellular-recordings, hippocampus, knockout, learning, mice, nmda}, month = {June}, pages = {1140263+}, posted-at = {2007-07-09 10:22:41}, priority = {2}, title = {Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network}, url = {http://dx.doi.org/10.1126/science.1140263}, year = {2007} }

TY - JOUR ID - citeulike:1373145 L3 - citeulike-article-id:1373145 TI - Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network JF - Science SP - 1140263 N2 - Forming distinct representations of multiple contexts, places and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-D-aspartate (NMDA) receptor, NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts. A significant reduction in the context-specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another. These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation. 10.1126/science.1140263 KW - dentate KW - extracellular-recordings KW - hippocampus KW - knockout KW - learning KW - mice KW - nmda AU - Mchugh, Thomas AU - Jones, Matthew AU - Quinn, Jennifer AU - Balthasar, Nina AU - Coppari, Roberto AU - Elmquist, Joel AU - Lowell, Bradford AU - Fanselow, Michael AU - Wilson, Matthew AU - Tonegawa, Susumu PY - 2007/06/07/ UR - http://dx.doi.org/10.1126/science.1140263 ER -