Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus

by: Jill K Leutgeb, Stefan Leutgeb, May-Britt Moser, Edvard I Moser

Science, Vol. 315, No. 5814. (16 February 2007), pp. 961-966.

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Abstract

Theoretical models have long pointed to the dentate gyrus as a possible source of neuronal pattern separation. In agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place-modulated granule cells in the dentate gyrus. When the environments are made more different, new cell populations are recruited in CA3 but not in the dentate gyrus. These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3. 10.1126/science.1135801

@article{citeulike:1109603, abstract = {Theoretical models have long pointed to the dentate gyrus as a possible source of neuronal pattern separation. In agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place-modulated granule cells in the dentate gyrus. When the environments are made more different, new cell populations are recruited in CA3 but not in the dentate gyrus. These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3. 10.1126/science.1135801}, author = {Leutgeb, Jill K. and Leutgeb, Stefan and Moser, May-Britt and Moser, Edvard I. }, citeulike-article-id = {1109603}, doi = {10.1126/science.1135801}, journal = {Science}, keywords = {ca3, dentate, hippocampus}, month = {February}, number = {5814}, pages = {961--966}, posted-at = {2007-02-16 10:01:03}, priority = {3}, title = {Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus}, url = {http://dx.doi.org/10.1126/science.1135801}, volume = {315}, year = {2007} }

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TY - JOUR ID - citeulike:1109603 L3 - citeulike-article-id:1109603 TI - Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus JF - Science VL - 315 IS - 5814 SP - 961 EP - 966 N2 - Theoretical models have long pointed to the dentate gyrus as a possible source of neuronal pattern separation. In agreement with predictions from these models, we show that minimal changes in the shape of the environment in which rats are exploring can substantially alter correlated activity patterns among place-modulated granule cells in the dentate gyrus. When the environments are made more different, new cell populations are recruited in CA3 but not in the dentate gyrus. These results imply a dual mechanism for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3. 10.1126/science.1135801 KW - ca3 KW - dentate KW - hippocampus AU - Leutgeb, Jill AU - Leutgeb, Stefan AU - Moser, May-Britt AU - Moser, Edvard PY - 2007/02/16/ UR - http://dx.doi.org/10.1126/science.1135801 ER -

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