ENDEAVOUR update: a web resource for gene prioritization in multiple species

@article{citeulike:2843033, abstract = {ENDEAVOUR (http://www.esat.kuleuven.be/endeavourweb; this web site is free and open to all users and there is no login requirement) is a web resource for the prioritization of candidate genes. Using a training set of genes known to be involved in a biological process of interest, our approach consists of (i) inferring several models (based on various genomic data sources), (ii) applying each model to the candidate genes to rank those candidates against the profile of the known genes and (iii) merging the several rankings into a global ranking of the candidate genes. In the present article, we describe the latest developments of ENDEAVOUR. First, we provide a web-based user interface, besides our Java client, to make ENDEAVOUR more universally accessible. Second, we support multiple species: in addition to Homo sapiens, we now provide gene prioritization for three major model organisms: Mus musculus, Rattus norvegicus and Caenorhabditis elegans. Third, ENDEAVOUR makes use of additional data sources and is now including numerous databases: ontologies and annotations, protein-protein interactions, cis-regulatory information, gene expression data sets, sequence information and text-mining data. We tested the novel version of ENDEAVOUR on 32 recent disease gene associations from the literature. Additionally, we describe a number of recent independent studies that made use of ENDEAVOUR to prioritize candidate genes for obesity and Type II diabetes, cleft lip and cleft palate, and pulmonary fibrosis. 10.1093/nar/gkn325}, author = {Tranchevent, Leon-Charles and Barriot, Roland and Yu, Shi and Vooren, Steven V. and Loo, Peter V. and Coessens, Bert and Moor, Bart D. and Aerts, Stein and Moreau, Yves }, citeulike-article-id = {2843033}, doi = {10.1093/nar/gkn325}, journal = {Nucl. Acids Res.}, keywords = {bioinformatics, candidate, function, gene, selection, webserver}, month = {May}, pages = {gkn325+}, posted-at = {2008-05-29 02:58:21}, priority = {2}, title = {ENDEAVOUR update: a web resource for gene prioritization in multiple species}, url = {http://dx.doi.org/10.1093/nar/gkn325}, year = {2008} }

TY - JOUR ID - citeulike:2843033 L3 - citeulike-article-id:2843033 TI - ENDEAVOUR update: a web resource for gene prioritization in multiple species JF - Nucl. Acids Res. SP - gkn325 N2 - ENDEAVOUR (http://www.esat.kuleuven.be/endeavourweb; this web site is free and open to all users and there is no login requirement) is a web resource for the prioritization of candidate genes. Using a training set of genes known to be involved in a biological process of interest, our approach consists of (i) inferring several models (based on various genomic data sources), (ii) applying each model to the candidate genes to rank those candidates against the profile of the known genes and (iii) merging the several rankings into a global ranking of the candidate genes. In the present article, we describe the latest developments of ENDEAVOUR. First, we provide a web-based user interface, besides our Java client, to make ENDEAVOUR more universally accessible. Second, we support multiple species: in addition to Homo sapiens, we now provide gene prioritization for three major model organisms: Mus musculus, Rattus norvegicus and Caenorhabditis elegans. Third, ENDEAVOUR makes use of additional data sources and is now including numerous databases: ontologies and annotations, protein-protein interactions, cis-regulatory information, gene expression data sets, sequence information and text-mining data. We tested the novel version of ENDEAVOUR on 32 recent disease gene associations from the literature. Additionally, we describe a number of recent independent studies that made use of ENDEAVOUR to prioritize candidate genes for obesity and Type II diabetes, cleft lip and cleft palate, and pulmonary fibrosis. 10.1093/nar/gkn325 KW - bioinformatics KW - candidate KW - function KW - gene KW - selection KW - webserver AU - Tranchevent, Leon-Charles AU - Barriot, Roland AU - Yu, Shi AU - Vooren, Steven AU - Loo, Peter AU - Coessens, Bert AU - Moor, Bart AU - Aerts, Stein AU - Moreau, Yves PY - 2008/05/28/ UR - http://dx.doi.org/10.1093/nar/gkn325 ER -