Protein kinases and protein phosphatases in prokaryotes: a genomic perspective.

by: Peter J Kennelly

FEMS Microbiol Lett, Vol. 206, No. 1. (Jan 2002), pp. 1-8.

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article-predikin, cell, kinase, phosphatase, phosphoprotein, phosphorylation, prokaryotic, protein

Abstract

For many years, the regulation of protein structure and function by phosphorylation and dephosphorylation was considered a relatively recent invention that arose independently in each phylogenetic domain. Over time, however, incidents of apparent domain trespass involving the presence of 'eukaryotic' protein kinases or protein phosphatases in prokaryotic organisms were reported with increasing frequency. Today, genomics has provided the means to examine the phylogenetic distribution of 'eukaryotic' protein kinases and protein phosphatases in a comprehensive and systematic manner. The results of these genome searches challenge previous conceptions concerning the origins and evolution of this versatile regulatory mechanism.

@article{Kennelly2002, abstract = {For many years, the regulation of protein structure and function by phosphorylation and dephosphorylation was considered a relatively recent invention that arose independently in each phylogenetic domain. Over time, however, incidents of apparent domain trespass involving the presence of 'eukaryotic' protein kinases or protein phosphatases in prokaryotic organisms were reported with increasing frequency. Today, genomics has provided the means to examine the phylogenetic distribution of 'eukaryotic' protein kinases and protein phosphatases in a comprehensive and systematic manner. The results of these genome searches challenge previous conceptions concerning the origins and evolution of this versatile regulatory mechanism.}, author = {Kennelly, Peter J. }, citeulike-article-id = {2054435}, journal = {FEMS Microbiol Lett}, keywords = {article-predikin, cell, kinase, phosphatase, phosphoprotein, phosphorylation, prokaryotic, protein}, month = {Jan}, number = {1}, pages = {1--8}, posted-at = {2007-12-04 03:22:13}, priority = {2}, title = {Protein kinases and protein phosphatases in prokaryotes: a genomic perspective.}, volume = {206}, year = {2002} }

RIS record

TY - JOUR ID - Kennelly2002 L3 - citeulike-article-id:2054435 TI - Protein kinases and protein phosphatases in prokaryotes: a genomic perspective. JF - FEMS Microbiol Lett VL - 206 IS - 1 SP - 1 EP - 8 N2 - For many years, the regulation of protein structure and function by phosphorylation and dephosphorylation was considered a relatively recent invention that arose independently in each phylogenetic domain. Over time, however, incidents of apparent domain trespass involving the presence of 'eukaryotic' protein kinases or protein phosphatases in prokaryotic organisms were reported with increasing frequency. Today, genomics has provided the means to examine the phylogenetic distribution of 'eukaryotic' protein kinases and protein phosphatases in a comprehensive and systematic manner. The results of these genome searches challenge previous conceptions concerning the origins and evolution of this versatile regulatory mechanism. KW - article-predikin KW - cell KW - kinase KW - phosphatase KW - phosphoprotein KW - phosphorylation KW - prokaryotic KW - protein AU - Kennelly, Peter PY - 2002/Jan// ER -

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