BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.

by: Zekun Guo, Wenwen Tang, Jian Yuan, Xinya Chen, Bo Wan, Xiuting Gu, Kuntian Luo, Yingli Wang, Long Yu

Biochem Biophys Res Commun, Vol. 347, No. 4. (Sep 2006), pp. 867-871.

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http://dx.doi.org/10.1016/j.bbrc.2006.06.…

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Abstract

Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA.

@article{Guo2006, abstract = {Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA.}, author = {Guo, Zekun and Tang, Wenwen and Yuan, Jian and Chen, Xinya and Wan, Bo and Gu, Xiuting and Luo, Kuntian and Wang, Yingli and Yu, Long }, citeulike-article-id = {2054426}, doi = {10.1016/j.bbrc.2006.06.178}, journal = {Biochem Biophys Res Commun}, keywords = {activation, alignment, amino-acid, amp-dependent, article-predikin, cyclic, data, enzyme, kinase, molecular, phosphorylation, protein, protein-serine-threonine, sequence, threonine}, month = {Sep}, number = {4}, pages = {867--871}, posted-at = {2007-12-04 03:22:12}, priority = {2}, title = {BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.}, url = {http://dx.doi.org/10.1016/j.bbrc.2006.06.178}, volume = {347}, year = {2006} }

RIS record

TY - JOUR ID - Guo2006 L3 - citeulike-article-id:2054426 TI - BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. JF - Biochem Biophys Res Commun VL - 347 IS - 4 SP - 867 EP - 871 N2 - Brain selective kinase 2 (BRSK2) has been identified as a member of AMPK related kinases. LKB1 can phosphorylate the Thr174 of BRSK2, increasing its activity >50-fold. In this study, we identified cAMP-dependent protein kinase A (PKA) as another upstream kinase of BRSK2, which can phosphorylate BRSK2 at Thr260. The association between these two proteins was confirmed by GST pull-down. Furthermore, our study indicated that the kinase activity of BRSK2 can be increased through phosphorylation by PKA. KW - activation KW - alignment KW - amino-acid KW - amp-dependent KW - article-predikin KW - cyclic KW - data KW - enzyme KW - kinase KW - molecular KW - phosphorylation KW - protein KW - protein-serine-threonine KW - sequence KW - threonine AU - Guo, Zekun AU - Tang, Wenwen AU - Yuan, Jian AU - Chen, Xinya AU - Wan, Bo AU - Gu, Xiuting AU - Luo, Kuntian AU - Wang, Yingli AU - Yu, Long PY - 2006/Sep// UR - http://dx.doi.org/10.1016/j.bbrc.2006.06.178 ER -

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