Distribution of IRAG and cGKI-isoforms in murine tissues.

@article{citeulike:2053689, abstract = {cGMP kinase I (cGKI) signaling modulates multiple physiological processes including smooth muscle relaxation. The expression of cGKI and its substrate IRAG (Inositol 1,4,5-trisphosphate receptor associated cGMP kinase substrate) was studied. IRAG and cGKI were colocalized in the smooth muscle of aorta and colon. IRAG was present in the thalamus and in most of the myenteric plexus in the absence of cGKI. Coexpression of IRAG and cGKIbeta or cGKIalpha in COS-7 cells revealed that IRAG recruits cGKIbeta but not cGKIalpha to the endoplasmic reticulum. These results suggest that IRAG may be involved in cGKI-dependent and -independent pathways.}, author = {Geiselh\"{o}ringer, A. and Gaisa, M. and Hofmann, F. and Schlossmann, J. }, citeulike-article-id = {2053689}, journal = {FEBS Lett}, keywords = {145-trisphosphate, animal, article-pka-pkg, c57bl, calcium, cell, channel, cos, cyclic, cytoplasmic, distribution, endoplasmic, fusion, gmp-dependent, hybridization, in, inbred, inositol, isoforms, kinase, mice, muscle, nuclear, phosphoprotein, protein, receptor, recombinant, reticulum, signal, situ, smooth, tissue, transduction}, number = {1-3}, pages = {19--22}, posted-at = {2007-12-04 01:53:36}, priority = {2}, title = {Distribution of IRAG and cGKI-isoforms in murine tissues.}, volume = {575}, year = {2004} }

TY - JOUR ID - citeulike:2053689 L3 - citeulike-article-id:2053689 TI - Distribution of IRAG and cGKI-isoforms in murine tissues. JF - FEBS Lett VL - 575 IS - 1-3 SP - 19 EP - 22 N2 - cGMP kinase I (cGKI) signaling modulates multiple physiological processes including smooth muscle relaxation. The expression of cGKI and its substrate IRAG (Inositol 1,4,5-trisphosphate receptor associated cGMP kinase substrate) was studied. IRAG and cGKI were colocalized in the smooth muscle of aorta and colon. IRAG was present in the thalamus and in most of the myenteric plexus in the absence of cGKI. Coexpression of IRAG and cGKIbeta or cGKIalpha in COS-7 cells revealed that IRAG recruits cGKIbeta but not cGKIalpha to the endoplasmic reticulum. These results suggest that IRAG may be involved in cGKI-dependent and -independent pathways. KW - 145-trisphosphate KW - animal KW - article-pka-pkg KW - c57bl KW - calcium KW - cell KW - channel KW - cos KW - cyclic KW - cytoplasmic KW - distribution KW - endoplasmic KW - fusion KW - gmp-dependent KW - hybridization KW - in KW - inbred KW - inositol KW - isoforms KW - kinase KW - mice KW - muscle KW - nuclear KW - phosphoprotein KW - protein KW - receptor KW - recombinant KW - reticulum KW - signal KW - situ KW - smooth KW - tissue KW - transduction AU - Geiselhöringer, A AU - Gaisa, M AU - Hofmann, F AU - Schlossmann, J PY - 2004/// ER -