A-kinase anchoring proteins take shape.

@article{citeulike:2042544, abstract = {A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates. Recently the structural basis for these protein-protein interactions has been elucidated by x-ray crystallography. Recent reports have identified AKAPs that bind to adenylyl cyclases to regulate cAMP synthesis and that sequester phosphodiesterases to break down this second messenger locally. Another emerging aspect of AKAP function is their role in integrating cAMP signaling with other signaling pathways. For example, molecular and genetic approaches have been used to show that the neuronal anchoring protein WAVE1 integrates signaling from PKA and Cdk5 to regulate actin polymerization and cytoskeletal events.}, address = {Howard Hughes Medical Institute, Oregon Health \& Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.}, author = {Beene, D. L. and Scott, J. D. }, citeulike-article-id = {2042544}, doi = {10.1016/j.ceb.2007.02.011}, issn = {0955-0674}, journal = {Curr Opin Cell Biol}, keywords = {akap, article-pka-pkg, camp, kinase, signaling, substrate}, month = {April}, number = {2}, pages = {192--198}, posted-at = {2007-12-02 08:14:04}, priority = {2}, title = {A-kinase anchoring proteins take shape.}, url = {http://dx.doi.org/10.1016/j.ceb.2007.02.011}, volume = {19}, year = {2007} }

TY - JOUR ID - citeulike:2042544 L3 - citeulike-article-id:2042544 TI - A-kinase anchoring proteins take shape. JF - Curr Opin Cell Biol VL - 19 IS - 2 SP - 192 EP - 198 AD - Howard Hughes Medical Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. SN - 0955-0674 N2 - A-kinase anchoring proteins (AKAPs) are signaling scaffolds that contribute to various aspects of cAMP signaling. They do this by tethering protein kinase-A to specific subcellular sites, thereby focusing its activity toward relevant substrates. Recently the structural basis for these protein-protein interactions has been elucidated by x-ray crystallography. Recent reports have identified AKAPs that bind to adenylyl cyclases to regulate cAMP synthesis and that sequester phosphodiesterases to break down this second messenger locally. Another emerging aspect of AKAP function is their role in integrating cAMP signaling with other signaling pathways. For example, molecular and genetic approaches have been used to show that the neuronal anchoring protein WAVE1 integrates signaling from PKA and Cdk5 to regulate actin polymerization and cytoskeletal events. KW - akap KW - article-pka-pkg KW - camp KW - kinase KW - signaling KW - substrate AU - Beene, DL AU - Scott, JD PY - 2007/04// UR - http://dx.doi.org/10.1016/j.ceb.2007.02.011 ER -