Cyclic nucleotide-dependent protein kinases.

by: JD Scott

Pharmacol Ther, Vol. 50, No. 1. (1991), pp. 123-145.

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Abstract

The actions of several hormones and neurotransmitters evoke signal transduction pathways which rapidly elevate the cytosolic concentrations of the intracellular messengers, cAMP and cGMP. The cyclic-nucleotide dependent protein kinases, cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG), are the major intracellular receptors of cAMP and cGMP. These enzymes become active upon binding respective cyclic nucleotides and modulate a diverse array of biochemical events through the phosphorylation of specific substrate proteins. The focus of this review is to describe the progress made in understanding the structure and function of both PKA and PKG.

@article{citeulike:1951989, abstract = {The actions of several hormones and neurotransmitters evoke signal transduction pathways which rapidly elevate the cytosolic concentrations of the intracellular messengers, cAMP and cGMP. The cyclic-nucleotide dependent protein kinases, cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG), are the major intracellular receptors of cAMP and cGMP. These enzymes become active upon binding respective cyclic nucleotides and modulate a diverse array of biochemical events through the phosphorylation of specific substrate proteins. The focus of this review is to describe the progress made in understanding the structure and function of both PKA and PKG.}, address = {Vollum Institute for Advanced Biomedical Research L-474, Portland, OR 97201-3098.}, author = {Scott, J. D. }, citeulike-article-id = {1951989}, issn = {0163-7258}, journal = {Pharmacol Ther}, keywords = {camp, cgmp, kinase}, number = {1}, pages = {123--145}, posted-at = {2007-11-21 13:31:48}, priority = {2}, title = {Cyclic nucleotide-dependent protein kinases.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1653962}, volume = {50}, year = {1991} }

RIS record

TY - JOUR ID - citeulike:1951989 L3 - citeulike-article-id:1951989 TI - Cyclic nucleotide-dependent protein kinases. JF - Pharmacol Ther VL - 50 IS - 1 SP - 123 EP - 145 AD - Vollum Institute for Advanced Biomedical Research L-474, Portland, OR 97201-3098. SN - 0163-7258 N2 - The actions of several hormones and neurotransmitters evoke signal transduction pathways which rapidly elevate the cytosolic concentrations of the intracellular messengers, cAMP and cGMP. The cyclic-nucleotide dependent protein kinases, cAMP-dependent protein kinase (PKA) and cGMP-dependent protein kinase (PKG), are the major intracellular receptors of cAMP and cGMP. These enzymes become active upon binding respective cyclic nucleotides and modulate a diverse array of biochemical events through the phosphorylation of specific substrate proteins. The focus of this review is to describe the progress made in understanding the structure and function of both PKA and PKG. KW - camp KW - cgmp KW - kinase AU - Scott, JD PY - 1991/// UR - http://view.ncbi.nlm.nih.gov/pubmed/1653962 ER -

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