Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering

@article{Ang2004, abstract = {With recent advances in biomolecular engineering, the bioremediation of persistent organic pollutants (POPs) using genetically modified microorganisms has become a rapidly growing area of research for environmental protection. Two main biomolecular approaches, rational design and directed evolution, have been developed to engineer enhanced microorganisms and enzymes for the biodegradation of POPs. This review describes the most recent developments and applications of these biomolecular tools for enhancing the capability of microorganisms to bioremediate three major classes of POPs - polycyclic aromatic hydrocabons (PAHs), polychlorinated biphenyls (PCBs) and pesticides. Most of the examples focused on the redesign of various features of the enzymes involved in the bioremediation of POPs, including the enzyme expression level, enzymatic activity and substrate specificity. Overall, the rapidly expanding potential of biomolecular engineering techniques has created the exciting potential of remediating some of the most recalcitrant and hazardous compounds in the environment.}, author = {Ang, Ee L. and Zhao, Huimin and Obbard, Jeffrey P. }, citeulike-article-id = {2717091}, doi = {10.1016/j.enzmictec.2004.07.024}, journal = {Enzyme and Microbial Technology}, keywords = {bioremediation, enzyme\_design}, month = {October}, number = {5}, pages = {487--496}, posted-at = {2008-04-25 10:05:23}, priority = {2}, title = {Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering}, url = {http://dx.doi.org/10.1016/j.enzmictec.2004.07.024}, volume = {37}, year = {2005} }

TY - JOUR ID - Ang2004 TI - Recent advances in the bioremediation of persistent organic pollutants via biomolecular engineering JF - Enzyme and Microbial Technology VL - 37 IS - 5 SP - 487 EP - 496 N2 - With recent advances in biomolecular engineering, the bioremediation of persistent organic pollutants (POPs) using genetically modified microorganisms has become a rapidly growing area of research for environmental protection. Two main biomolecular approaches, rational design and directed evolution, have been developed to engineer enhanced microorganisms and enzymes for the biodegradation of POPs. This review describes the most recent developments and applications of these biomolecular tools for enhancing the capability of microorganisms to bioremediate three major classes of POPs - polycyclic aromatic hydrocabons (PAHs), polychlorinated biphenyls (PCBs) and pesticides. Most of the examples focused on the redesign of various features of the enzymes involved in the bioremediation of POPs, including the enzyme expression level, enzymatic activity and substrate specificity. Overall, the rapidly expanding potential of biomolecular engineering techniques has created the exciting potential of remediating some of the most recalcitrant and hazardous compounds in the environment. KW - bioremediation KW - enzyme_design AU - Ang, Ee AU - Zhao, Huimin AU - Obbard, Jeffrey PY - 2005/10/03/ UR - http://dx.doi.org/10.1016/j.enzmictec.2004.07.024 ER -