Enhancing catalytic promiscuity for biocatalysis.

@article{Kazlauskas2005, abstract = {Catalytic promiscuity - the ability of a single active site to catalyse more than one chemical transformation - has a natural role in evolution and occasionally in biosynthesis of secondary metabolites. Catalytic promiscuity is more widespread than often recognized. Recent success in adding and enhancing such catalytic activities by protein engineering suggests new potential applications in enzyme-catalyzed organic synthesis.}, address = {University of Minnesota, Department of Biochemistry, Molecular Biology \& Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108, USA. rjk@umn.edu}, author = {Kazlauskas, R. J. }, citeulike-article-id = {1135436}, doi = {10.1016/j.cbpa.2005.02.008}, issn = {1367-5931}, journal = {Curr Opin Chem Biol}, keywords = {enzyme\_design, opinion}, month = {April}, number = {2}, pages = {195--201}, posted-at = {2008-04-22 11:59:01}, priority = {2}, title = {Enhancing catalytic promiscuity for biocatalysis.}, url = {http://dx.doi.org/10.1016/j.cbpa.2005.02.008}, volume = {9}, year = {2005} }

TY - JOUR ID - Kazlauskas2005 TI - Enhancing catalytic promiscuity for biocatalysis. JF - Curr Opin Chem Biol VL - 9 IS - 2 SP - 195 EP - 201 AD - University of Minnesota, Department of Biochemistry, Molecular Biology & Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108, USA. rjk@umn.edu SN - 1367-5931 N2 - Catalytic promiscuity - the ability of a single active site to catalyse more than one chemical transformation - has a natural role in evolution and occasionally in biosynthesis of secondary metabolites. Catalytic promiscuity is more widespread than often recognized. Recent success in adding and enhancing such catalytic activities by protein engineering suggests new potential applications in enzyme-catalyzed organic synthesis. KW - enzyme_design KW - opinion AU - Kazlauskas, RJ PY - 2005/04// UR - http://dx.doi.org/10.1016/j.cbpa.2005.02.008 ER -