Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase.

@article{citeulike:1572465, abstract = {Pineal melatonin synthesis (serotonin --> N-acetylserotonin --> melatonin) is severely compromised in most inbred strains of mice, in many cases because serotonin is not acetylated by serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT). We have found that in the C57BL/6J strain, AANAT mRNA encodes a severely truncated AANAT protein, because a pseudo-exon containing a stop codon is spliced in. This is the first identification of a natural mutation which knocks down melatonin synthesis. The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity.}, address = {Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.}, author = {Roseboom, P. H. and Namboodiri, M. A. and Zimonjic, D. B. and Popescu, N. C. and Rodriguez, I. R. and Gastel, J. A. and Klein, D. C. }, citeulike-article-id = {1572465}, issn = {0169-328X}, journal = {Brain Res Mol Brain Res}, keywords = {melatonin}, month = {December}, number = {1}, pages = {189--197}, posted-at = {2007-08-17 13:59:37}, priority = {2}, title = {Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9838107}, volume = {63}, year = {1998} }

TY - JOUR ID - citeulike:1572465 L3 - citeulike-article-id:1572465 TI - Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase. JF - Brain Res Mol Brain Res VL - 63 IS - 1 SP - 189 EP - 197 AD - Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. SN - 0169-328X N2 - Pineal melatonin synthesis (serotonin --> N-acetylserotonin --> melatonin) is severely compromised in most inbred strains of mice, in many cases because serotonin is not acetylated by serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT). We have found that in the C57BL/6J strain, AANAT mRNA encodes a severely truncated AANAT protein, because a pseudo-exon containing a stop codon is spliced in. This is the first identification of a natural mutation which knocks down melatonin synthesis. The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity. KW - melatonin AU - Roseboom, PH AU - Namboodiri, MA AU - Zimonjic, DB AU - Popescu, NC AU - Rodriguez, IR AU - Gastel, JA AU - Klein, DC PY - 1998/12/10/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9838107 ER -