Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers

@article{citeulike:2858430, abstract = {In this review, we highlight the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers. The synthesis of this type of MSN materials is described along with the current methods for controlling the structural properties and chemical functionalization for biotechnological and biomedical applications. We summarized the advantages of using MSN for several drug delivery applications. The recent investigations of the biocompatibility of MSN in vitro are discussed. We also describe the exciting progress on using MSN to penetrate various cell membranes in animal and plant cells. The novel concept of gatekeeping is introduced and applied to the design of a variety of stimuli-responsive nanodevices. We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.}, author = {Slowing, Igor I. and Vivero-Escoto, Juan L. and Wu, Chia-Wen and Lin, Victor S. }, citeulike-article-id = {2858430}, doi = {http://dx.doi.org/10.1016/j.addr.2008.03.012}, journal = {Advanced Drug Delivery Reviews}, keywords = {drug\_delivery, mesoporous\_silica, nanoparticles, review}, posted-at = {2008-06-03 08:10:25}, priority = {2}, title = {Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers}, url = {http://dx.doi.org/10.1016/j.addr.2008.03.012}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:2858430 L3 - citeulike-article-id:2858430 TI - Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers JF - Advanced Drug Delivery Reviews VL - In Press, Corrected Proof N2 - In this review, we highlight the recent research developments of a series of surface-functionalized mesoporous silica nanoparticle (MSN) materials as efficient drug delivery carriers. The synthesis of this type of MSN materials is described along with the current methods for controlling the structural properties and chemical functionalization for biotechnological and biomedical applications. We summarized the advantages of using MSN for several drug delivery applications. The recent investigations of the biocompatibility of MSN in vitro are discussed. We also describe the exciting progress on using MSN to penetrate various cell membranes in animal and plant cells. The novel concept of gatekeeping is introduced and applied to the design of a variety of stimuli-responsive nanodevices. We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents. KW - drug_delivery KW - mesoporous_silica KW - nanoparticles KW - review AU - Slowing, Igor AU - Vivero-Escoto, Juan AU - Wu, Chia-Wen AU - Lin, Victor UR - http://dx.doi.org/10.1016/j.addr.2008.03.012 ER -