Mesoporous Silica Nanoparticles Inhibit Cellular Respiration

@article{citeulike:2819072, abstract = {Abstract: We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25500 µg/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 µg/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 µg/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles.}, address = {Department of Pediatrics, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, Department of Chemistry, Syracuse University, CST, 1-014, Syracuse, New York 13244, and Public Health Research Institute, 225 Warren Street, Newark, New Jersey 07103}, author = {Tao, Zhimin and Morrow, Matthew P. and Asefa, Tewodros and Sharma, Krishna K. and Duncan, Cole and Anan, Abhishek and Penefsky, Harvey S. and Goodisman, Jerry and Souid, Abdul-Kader }, citeulike-article-id = {2819072}, doi = {http://dx.doi.org/10.1021/nl080250u}, journal = {Nano Lett.}, keywords = {cytotoxicity, in\_vitro\_toxicity, mesoporous\_silica, nanoparticles}, month = {May}, number = {5}, pages = {1517--1526}, posted-at = {2008-05-21 10:40:22}, priority = {2}, title = {Mesoporous Silica Nanoparticles Inhibit Cellular Respiration}, url = {http://dx.doi.org/10.1021/nl080250u}, volume = {8}, year = {2008} }

TY - JOUR ID - citeulike:2819072 L3 - citeulike-article-id:2819072 TI - Mesoporous Silica Nanoparticles Inhibit Cellular Respiration JF - Nano Lett. VL - 8 IS - 5 SP - 1517 EP - 1526 AD - Department of Pediatrics, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, Department of Chemistry, Syracuse University, CST, 1-014, Syracuse, New York 13244, and Public Health Research Institute, 225 Warren Street, Newark, New Jersey 07103 N2 - Abstract: We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25500 µg/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 µg/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 µg/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles. KW - cytotoxicity KW - in_vitro_toxicity KW - mesoporous_silica KW - nanoparticles AU - Tao, Zhimin AU - Morrow, Matthew AU - Asefa, Tewodros AU - Sharma, Krishna AU - Duncan, Cole AU - Anan, Abhishek AU - Penefsky, Harvey AU - Goodisman, Jerry AU - Souid, Abdul-Kader PY - 2008/05/14/ UR - http://dx.doi.org/10.1021/nl080250u ER -