Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?

by: Pascale Leroueil, Seungpyo Hong, Almut Mecke, James Baker, Bradford Orr, Banaszak

Acc. Chem. Res., Vol. 40, No. 5. (15 May 2007), pp. 335-342.

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DOI, American Chem. Soc. Publications

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Abstract

Abstract: Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phasefluid, liquid crystalline, or gelof the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microsopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy.

@article{citeulike:2805198, abstract = {Abstract: Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phasefluid, liquid crystalline, or gelof the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microsopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy.}, address = {Program in Macromolecular Science and Engineering, Departments of Chemistry and Physics, Graham Environmental Sustainability Institute, and Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109}, author = {Leroueil, Pascale and Hong, Seungpyo and Mecke, Almut and Baker, James and Orr, Bradford and Banaszak}, citeulike-article-id = {2805198}, doi = {10.1021/ar600012y}, journal = {Acc. Chem. Res.}, keywords = {cell\_interaction, nanoparticles}, month = {May}, number = {5}, pages = {335--342}, posted-at = {2008-05-16 13:30:43}, priority = {1}, title = {Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face?}, url = {http://dx.doi.org/10.1021/ar600012y}, volume = {40}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:2805198 L3 - citeulike-article-id:2805198 TI - Nanoparticle Interaction with Biological Membranes: Does Nanotechnology Present a Janus Face? JF - Acc. Chem. Res. VL - 40 IS - 5 SP - 335 EP - 342 AD - Program in Macromolecular Science and Engineering, Departments of Chemistry and Physics, Graham Environmental Sustainability Institute, and Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, MI 48109 N2 - Abstract: Polycationic organic nanoparticles are shown to disrupt model biological membranes and living cell membranes at nanomolar concentrations. The degree of disruption is shown to be related to nanoparticle size and charge, as well as to the phasefluid, liquid crystalline, or gelof the biological membrane. Disruption events on model membranes have been directly imaged using scanning probe microsopy, whereas disruption events on living cells have been analyzed using cytosolic enzyme leakage assays, dye diffusion assays, and fluorescence microscopy. KW - cell_interaction KW - nanoparticles AU - Leroueil, Pascale AU - Hong, Seungpyo AU - Mecke, Almut AU - Baker, James AU - Orr, Bradford AU - Banaszak PY - 2007/05/15/ UR - http://dx.doi.org/10.1021/ar600012y ER -

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