The transcriptional repressor Snail promotes mammary tumor recurrence.

@article{citeulike:381469, abstract = {Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and represents the principal cause of death from this disease. Using a conditional transgenic mouse model for the recurrence of HER2/neu-induced mammary tumors, we demonstrate that the transcriptional repressor Snail is spontaneously upregulated in recurrent tumors in vivo and that recurrence is accompanied by epithelial-to-mesenchymal transition (EMT). Consistent with a causal role for Snail in these processes, we show that Snail is sufficient to induce EMT in primary tumor cells, that Snail is sufficient to promote mammary tumor recurrence in vivo, and that high levels of Snail predict decreased relapse-free survival in women with breast cancer. In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence.}, address = {Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.}, author = {Moody, S. E. and Perez, D. and Pan, T. C. and Sarkisian, C. J. and Portocarrero, C. P. and Sterner, C. J. and Notorfrancesco, K. L. and Cardiff, R. D. and Chodosh, L. A. }, citeulike-article-id = {381469}, doi = {http://dx.doi.org/10.1016/j.ccr.2005.07.009}, issn = {1535-6108}, journal = {Cancer Cell}, keywords = {breastcancer, snail}, month = {September}, number = {3}, pages = {197--209}, posted-at = {2005-11-05 08:47:22}, priority = {2}, title = {The transcriptional repressor Snail promotes mammary tumor recurrence.}, url = {http://dx.doi.org/10.1016/j.ccr.2005.07.009}, volume = {8}, year = {2005} }

TY - JOUR ID - citeulike:381469 L3 - citeulike-article-id:381469 TI - The transcriptional repressor Snail promotes mammary tumor recurrence. JF - Cancer Cell VL - 8 IS - 3 SP - 197 EP - 209 AD - Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA. SN - 1535-6108 N2 - Breast cancer recurrence is a fundamental clinical manifestation of tumor progression and represents the principal cause of death from this disease. Using a conditional transgenic mouse model for the recurrence of HER2/neu-induced mammary tumors, we demonstrate that the transcriptional repressor Snail is spontaneously upregulated in recurrent tumors in vivo and that recurrence is accompanied by epithelial-to-mesenchymal transition (EMT). Consistent with a causal role for Snail in these processes, we show that Snail is sufficient to induce EMT in primary tumor cells, that Snail is sufficient to promote mammary tumor recurrence in vivo, and that high levels of Snail predict decreased relapse-free survival in women with breast cancer. In aggregate, our observations strongly implicate Snail in the process of breast cancer recurrence. KW - breastcancer KW - snail AU - Moody, SE AU - Perez, D AU - Pan, TC AU - Sarkisian, CJ AU - Portocarrero, CP AU - Sterner, CJ AU - Notorfrancesco, KL AU - Cardiff, RD AU - Chodosh, LA PY - 2005/09// UR - http://dx.doi.org/10.1016/j.ccr.2005.07.009 ER -