The role of microRNAs in cancer: No small matter

@article{citeulike:1439423, abstract = {MicroRNAs are a recently discovered class of small, evolutionarily conserved, RNA molecules that negatively regulate gene expression at the post-transcriptional level. Mature microRNAs of approximately 20-22 nucleotides are formed from longer primary transcripts by two sequential processing steps mediated by a nuclear (Drosha) and a cytoplasmic (Dicer) RNAse III endonuclease. In the context of a protein complex, the RNA-induced silencing complex (RISC), microRNAs base-pair with target messenger RNA sequences causing translational repression and/or messenger RNA degradation. MicroRNAs have been implicated in the control of many fundamental cellular and physiological processes such as tissue development, cellular differentiation and proliferation, metabolic and signalling pathways, apoptosis and stem cell maintenance. Mounting evidence indicates that microRNAs also play a significant role in cellular transformation and carcinogenesis acting either as oncogenes or tumour suppressors. This review briefly introduces microRNAs in a historical perspective and focusses on the biogenesis of microRNAs, their mode of action, mammalian microRNA functions with emphasis on their involvement in disease - particularly cancer - and their potential therapeutic use.}, author = {Wiemer, Erik A. }, citeulike-article-id = {1439423}, journal = {European Journal of Cancer}, keywords = {cancer, microrna}, month = {July}, number = {10}, pages = {1529--1544}, posted-at = {2008-03-22 02:01:45}, priority = {2}, title = {The role of microRNAs in cancer: No small matter}, url = {http://www.sciencedirect.com/science/article/B6T68-4NT93RK-1/2/6f300b612464b75b5963f930b73d140f}, volume = {43}, year = {2007} }

TY - JOUR ID - citeulike:1439423 L3 - citeulike-article-id:1439423 TI - The role of microRNAs in cancer: No small matter JF - European Journal of Cancer VL - 43 IS - 10 SP - 1529 EP - 1544 N2 - MicroRNAs are a recently discovered class of small, evolutionarily conserved, RNA molecules that negatively regulate gene expression at the post-transcriptional level. Mature microRNAs of approximately 20-22 nucleotides are formed from longer primary transcripts by two sequential processing steps mediated by a nuclear (Drosha) and a cytoplasmic (Dicer) RNAse III endonuclease. In the context of a protein complex, the RNA-induced silencing complex (RISC), microRNAs base-pair with target messenger RNA sequences causing translational repression and/or messenger RNA degradation. MicroRNAs have been implicated in the control of many fundamental cellular and physiological processes such as tissue development, cellular differentiation and proliferation, metabolic and signalling pathways, apoptosis and stem cell maintenance. Mounting evidence indicates that microRNAs also play a significant role in cellular transformation and carcinogenesis acting either as oncogenes or tumour suppressors. This review briefly introduces microRNAs in a historical perspective and focusses on the biogenesis of microRNAs, their mode of action, mammalian microRNA functions with emphasis on their involvement in disease - particularly cancer - and their potential therapeutic use. KW - cancer KW - microrna AU - Wiemer, Erik PY - 2007/07// UR - http://www.sciencedirect.com/science/article/B6T68-4NT93RK-1/2/6f300b612464b75b5963f930b73d140f ER -