Urinary hCG patterns during the week following implantation

@article{citeulike:3038130, abstract = {BACKGROUNDHuman chorionic gonadotrophin (hCG) is used to monitor pregnancy status. Yet the pattern of hCG excretion in the first week following implantation has not been adequately described.Therefore the aim of this study was to describe the average profile of hCG and its variability during the 7 days following estimated implantation in a population of naturally conceived pregnancies. METHODSWe measured daily hCG concentrations in first-morning urine for 142 clinical pregnancies from women with no known fertility problems. Mixed-effects regression models were used to estimate the hCG trajectory and its variability in relation to pregnancy outcomes. RESULTShCG rose 3-fold between the day of detection and the next day (95\% CI = 2.7-3.4). The relative rate of rise decreased thereafter, reaching 1.6-fold (95\% CI = 1.5-1.8) between days 6 and 7. HCG levels followed a log-quadratic trajectory, and the patterns of rise were unrelated to number of fetuses, risk of spontaneous abortion or sex of the baby. Later implantations (after 10 luteal days) produced slower rates of increase. CONCLUSIONSAlthough mean hCG follows a log-quadratic trajectory during the first week of detectability, there is high variability across pregnancies. Later implantation may reflect characteristics of the uterus or conceptus that slow hCG production. 10.1093/humrep/dem397}, author = {Nepomnaschy, P. A. and Weinberg, C. R. and Wilcox, A. J. and Baird, D. D. }, citeulike-article-id = {3038130}, doi = {http://dx.doi.org/10.1093/humrep/dem397}, journal = {Hum. Reprod.}, keywords = {hcg}, month = {February}, number = {2}, pages = {271--277}, posted-at = {2008-07-24 03:25:19}, priority = {2}, title = {Urinary hCG patterns during the week following implantation}, url = {http://dx.doi.org/10.1093/humrep/dem397}, volume = {23}, year = {2008} }

TY - JOUR ID - citeulike:3038130 L3 - citeulike-article-id:3038130 TI - Urinary hCG patterns during the week following implantation JF - Hum. Reprod. VL - 23 IS - 2 SP - 271 EP - 277 N2 - BACKGROUNDHuman chorionic gonadotrophin (hCG) is used to monitor pregnancy status. Yet the pattern of hCG excretion in the first week following implantation has not been adequately described.Therefore the aim of this study was to describe the average profile of hCG and its variability during the 7 days following estimated implantation in a population of naturally conceived pregnancies. METHODSWe measured daily hCG concentrations in first-morning urine for 142 clinical pregnancies from women with no known fertility problems. Mixed-effects regression models were used to estimate the hCG trajectory and its variability in relation to pregnancy outcomes. RESULTShCG rose 3-fold between the day of detection and the next day (95% CI = 2.7-3.4). The relative rate of rise decreased thereafter, reaching 1.6-fold (95% CI = 1.5-1.8) between days 6 and 7. HCG levels followed a log-quadratic trajectory, and the patterns of rise were unrelated to number of fetuses, risk of spontaneous abortion or sex of the baby. Later implantations (after 10 luteal days) produced slower rates of increase. CONCLUSIONSAlthough mean hCG follows a log-quadratic trajectory during the first week of detectability, there is high variability across pregnancies. Later implantation may reflect characteristics of the uterus or conceptus that slow hCG production. 10.1093/humrep/dem397 KW - hcg AU - Nepomnaschy, PA AU - Weinberg, CR AU - Wilcox, AJ AU - Baird, DD PY - 2008/02/01/ UR - http://dx.doi.org/10.1093/humrep/dem397 ER -