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Linear motifs: evolutionary interaction switches.

by: V Neduva, RB Russell
FEBS Lett, Vol. 579, No. 15. (13 June 2005), pp. 3342-3345.


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Linear motifs are short sequence patterns associated with a particular function. They differ fundamentally from longer, globular protein domains in terms of their binding affinities, evolution and in how they are found experimentally or computationally. In this Minireview, we discuss various aspects of these critically important functional regions.


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