Control of stress-dependent cardiac growth and gene expression by a MicroRNA.

by: E van Rooij, LB Sutherland, X Qi, JA Richardson, J Hill, EN Olson

Science, Vol. 316, No. 5824. (27 April 2007), pp. 575-579.

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Abstract

The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alphaMHC) and up-regulation of betaMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the alphaMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of betaMHC in response to stress and hypothyroidism. Thus, the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.

@article{citeulike:1302129, abstract = {The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alphaMHC) and up-regulation of betaMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the alphaMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of betaMHC in response to stress and hypothyroidism. Thus, the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.}, address = {Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA.}, author = {van Rooij, E. and Sutherland, L. B. and Qi, X. and Richardson, J. A. and Hill, J. and Olson, E. N. }, citeulike-article-id = {1302129}, doi = {10.1126/science.1139089}, issn = {1095-9203}, journal = {Science}, keywords = {cardiac, microrna, mir-208, regulation}, month = {April}, number = {5824}, pages = {575--579}, posted-at = {2008-05-14 16:37:08}, priority = {2}, title = {Control of stress-dependent cardiac growth and gene expression by a MicroRNA.}, url = {http://dx.doi.org/10.1126/science.1139089}, volume = {316}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1302129 L3 - citeulike-article-id:1302129 TI - Control of stress-dependent cardiac growth and gene expression by a MicroRNA. JF - Science VL - 316 IS - 5824 SP - 575 EP - 579 AD - Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9148, USA. SN - 1095-9203 N2 - The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alphaMHC) and up-regulation of betaMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the alphaMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of betaMHC in response to stress and hypothyroidism. Thus, the alphaMHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208. KW - cardiac KW - microrna KW - mir-208 KW - regulation AU - van Rooij, E AU - Sutherland, LB AU - Qi, X AU - Richardson, JA AU - Hill, J AU - Olson, EN PY - 2007/04/27/ UR - http://dx.doi.org/10.1126/science.1139089 ER -

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