Evolution of microbial virulence: the benefits of stress.

@article{citeulike:2933126, abstract = {Although genome sequencing of microbial pathogens has shed light on the evolution of virulence, the drivers of the gain and loss of genes and of pathogenicity islands (gene clusters), which contribute to the emergence of new disease outbreaks, are unclear. Recent experiments with the bean pathogen Pseudomonas syringae pv. phaseolicola illustrate how exposure to resistance mechanisms acts as the driving force for genome reorganization. Here we argue that the antimicrobial conditions generated by host defences can accelerate the generation of genome rearrangements that provide selective advantages to the invading microbe. Similar exposure to environmental stress outside the host could also drive the horizontal gene transfer that has led to the evolution of pathogenicity towards both animals and plants.}, address = {Centre for Research in Plant Science, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, UK.}, author = {Arnold, D. L. and Jackson, R. W. and Waterfield, N. R. and Mansfield, J. W. }, citeulike-article-id = {2933126}, doi = {10.1016/j.tig.2007.03.017}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, keywords = {ttss}, month = {June}, number = {6}, pages = {293--300}, posted-at = {2008-06-27 10:15:08}, priority = {3}, title = {Evolution of microbial virulence: the benefits of stress.}, url = {http://dx.doi.org/10.1016/j.tig.2007.03.017}, volume = {23}, year = {2007} }

TY - JOUR ID - citeulike:2933126 L3 - citeulike-article-id:2933126 TI - Evolution of microbial virulence: the benefits of stress. JF - Trends in genetics : TIG VL - 23 IS - 6 SP - 293 EP - 300 AD - Centre for Research in Plant Science, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol, UK. SN - 0168-9525 N2 - Although genome sequencing of microbial pathogens has shed light on the evolution of virulence, the drivers of the gain and loss of genes and of pathogenicity islands (gene clusters), which contribute to the emergence of new disease outbreaks, are unclear. Recent experiments with the bean pathogen Pseudomonas syringae pv. phaseolicola illustrate how exposure to resistance mechanisms acts as the driving force for genome reorganization. Here we argue that the antimicrobial conditions generated by host defences can accelerate the generation of genome rearrangements that provide selective advantages to the invading microbe. Similar exposure to environmental stress outside the host could also drive the horizontal gene transfer that has led to the evolution of pathogenicity towards both animals and plants. KW - ttss AU - Arnold, DL AU - Jackson, RW AU - Waterfield, NR AU - Mansfield, JW PY - 2007/06// UR - http://dx.doi.org/10.1016/j.tig.2007.03.017 ER -