Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons.

by: H Shogomori, MA Burack, G Banker, AH Futerman

FEBS Lett, Vol. 458, No. 2. (17 September 1999), pp. 107-111.

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Abstract

Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated.

@article{citeulike:770892, abstract = {Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated.}, address = {Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel.}, author = {Shogomori, H. and Burack, M. A. and Banker, G. and Futerman, A. H. }, citeulike-article-id = {770892}, issn = {0014-5793}, journal = {FEBS Lett}, keywords = {axon, lipids}, month = {September}, number = {2}, pages = {107--111}, posted-at = {2006-07-24 09:51:18}, priority = {0}, title = {Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10481046}, volume = {458}, year = {1999} }

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TY - JOUR ID - citeulike:770892 L3 - citeulike-article-id:770892 TI - Gangliosides GM1 and GD1b are not polarized in mature hippocampal neurons. JF - FEBS Lett VL - 458 IS - 2 SP - 107 EP - 111 AD - Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel. SN - 0014-5793 N2 - Analysis of the binding of cholera toxin to ganglioside GM1 in both living and fixed neurons, and comparison with the distribution of defined axonal and dendritic proteins, demonstrates that ganglioside GM1 is distributed in a non-polarized manner over the axonal and dendritic plasma membranes of mature, cultured hippocampal neurons. Likewise, ganglioside GD1b is also distributed in a non-polarized manner. These results suggest that a recent report [Ledesma, M.D. et al. EMBO J. 18 (1999) 1761-1771] proposing that ganglioside GM1 is highly enriched on the axonal versus dendritic membrane of hippocampal neurons may need to be re-evaluated. KW - axon KW - lipids AU - Shogomori, H AU - Burack, MA AU - Banker, G AU - Futerman, AH PY - 1999/09/17/ UR - http://view.ncbi.nlm.nih.gov/pubmed/10481046 ER -

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