Secretory trafficking in neuronal dendrites.

by: AC Horton, MD Ehlers

Nat Cell Biol, Vol. 6, No. 7. (July 2004), pp. 585-591.

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Abstract

The neuronal secretory pathway represents the intracellular route for proteins involved in synaptic transmission and plasticity, as well as lipids required for outgrowth and remodelling of dendrites and axons. Although neurons use the same secretory compartments as other eukaryotic cells, the enormous distances involved, as well as the unique morphology of the neuron and its signalling requirements, challenge canonical models of secretory pathway organization. Here, we review evidence for a distributed secretory pathway in neurons, suggest mechanisms that may regulate secretory compartment distribution, and discuss the implications of a distributed secretory pathway for neuronal morphogenesis and neural-circuit plasticity.

@article{citeulike:767982, abstract = {The neuronal secretory pathway represents the intracellular route for proteins involved in synaptic transmission and plasticity, as well as lipids required for outgrowth and remodelling of dendrites and axons. Although neurons use the same secretory compartments as other eukaryotic cells, the enormous distances involved, as well as the unique morphology of the neuron and its signalling requirements, challenge canonical models of secretory pathway organization. Here, we review evidence for a distributed secretory pathway in neurons, suggest mechanisms that may regulate secretory compartment distribution, and discuss the implications of a distributed secretory pathway for neuronal morphogenesis and neural-circuit plasticity.}, address = {Department of Neurobiology, Duke University Medical Center, Box 3209 Durham, NC 27710, USA.}, author = {Horton, A. C. and Ehlers, M. D. }, citeulike-article-id = {767982}, doi = {10.1038/ncb0704-585}, issn = {1465-7392}, journal = {Nat Cell Biol}, keywords = {dendrites, intracellular, re\_golgi, review, somatodendritic, trafficking}, month = {July}, number = {7}, pages = {585--591}, posted-at = {2006-07-21 09:26:56}, priority = {0}, title = {Secretory trafficking in neuronal dendrites.}, url = {http://dx.doi.org/10.1038/ncb0704-585}, volume = {6}, year = {2004} }

RIS record

TY - JOUR ID - citeulike:767982 L3 - citeulike-article-id:767982 TI - Secretory trafficking in neuronal dendrites. JF - Nat Cell Biol VL - 6 IS - 7 SP - 585 EP - 591 AD - Department of Neurobiology, Duke University Medical Center, Box 3209 Durham, NC 27710, USA. SN - 1465-7392 N2 - The neuronal secretory pathway represents the intracellular route for proteins involved in synaptic transmission and plasticity, as well as lipids required for outgrowth and remodelling of dendrites and axons. Although neurons use the same secretory compartments as other eukaryotic cells, the enormous distances involved, as well as the unique morphology of the neuron and its signalling requirements, challenge canonical models of secretory pathway organization. Here, we review evidence for a distributed secretory pathway in neurons, suggest mechanisms that may regulate secretory compartment distribution, and discuss the implications of a distributed secretory pathway for neuronal morphogenesis and neural-circuit plasticity. KW - dendrites KW - intracellular KW - re_golgi KW - review KW - somatodendritic KW - trafficking AU - Horton, AC AU - Ehlers, MD PY - 2004/07// UR - http://dx.doi.org/10.1038/ncb0704-585 ER -

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