A targeting motif involved in sodium channel clustering at the axonal initial segment.

@article{citeulike:704886, abstract = {The sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Nav1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Nav1.2II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, this motif may play a fundamental role in controlling electrical excitability during development and plasticity.}, address = {Institut National de la Sant\'{e} et de la Recherche M\'{e}dicale Unit\'{e} 464, Institut Jean Roche, Universit\'{e} de la M\'{e}diterran\'{e}e, Facult\'{e} de M\'{e}decine Secteur-Nord, Boulevard P. Dramard, 13916 Marseille Cedex 20, France.}, author = {Garrido, J. J. and Giraud, P. and Carlier, E. and Fernandes, F. and Moussif, A. and Fache, M. P. and Debanne, D. and Dargent, B. }, citeulike-article-id = {704886}, doi = {10.1126/science.1085167}, issn = {1095-9203}, journal = {Science}, keywords = {ais, ankyrin, axon, endocytosis, ion\_channels, motif, nav, somatodendritic, targeting}, month = {June}, number = {5628}, pages = {2091--2094}, posted-at = {2006-07-21 10:08:42}, priority = {0}, title = {A targeting motif involved in sodium channel clustering at the axonal initial segment.}, url = {http://dx.doi.org/10.1126/science.1085167}, volume = {300}, year = {2003} }

TY - JOUR ID - citeulike:704886 L3 - citeulike-article-id:704886 TI - A targeting motif involved in sodium channel clustering at the axonal initial segment. JF - Science VL - 300 IS - 5628 SP - 2091 EP - 2094 AD - Institut National de la Santé et de la Recherche Médicale Unité 464, Institut Jean Roche, Université de la Méditerranée, Faculté de Médecine Secteur-Nord, Boulevard P. Dramard, 13916 Marseille Cedex 20, France. SN - 1095-9203 N2 - The sorting of sodium channels to axons and the formation of clusters are of primary importance for neuronal electrogenesis. Here, we showed that the cytoplasmic loop connecting domains II and III of the Nav1 subunit contains a determinant conferring compartmentalization in the axonal initial segment of rat hippocampal neurons. Expression of a soluble Nav1.2II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, this motif may play a fundamental role in controlling electrical excitability during development and plasticity. KW - ais KW - ankyrin KW - axon KW - endocytosis KW - ion_channels KW - motif KW - nav KW - somatodendritic KW - targeting AU - Garrido, JJ AU - Giraud, P AU - Carlier, E AU - Fernandes, F AU - Moussif, A AU - Fache, MP AU - Debanne, D AU - Dargent, B PY - 2003/06/27/ UR - http://dx.doi.org/10.1126/science.1085167 ER -