K+ Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons

@article{citeulike:2794345, abstract = {Summary Fast-spiking cells (FS cells) are a prominent subtype of neocortical GABAergic interneurons with important functional roles. Multiple FS cell properties are coordinated for rapid response. Here, we describe an FS cell feature that serves to gate the powerful inhibition produced by FS cell activity. We show that FS cells in layer 2/3 barrel cortex possess a dampening mechanism mediated by Kv1.1-containing potassium channels localized to the axon initial segment. These channels powerfully regulate action potential threshold and allow FS cells to respond preferentially to large inputs that are fast enough to "outrun" Kv1 activation. In addition, Kv1.1 channel blockade converts the delay-type discharge pattern of FS cells to one of continuous fast spiking without influencing the high-frequency firing that defines FS cells. Thus, Kv1 channels provide a key counterbalance to the established rapid-response characteristics of FS cells, regulating excitability through a unique combination of electrophysiological properties and discrete subcellular localization.}, author = {Goldberg, Ethan M. and Clark, Brian D. and Zagha, Edward and Nahmani, Mark and Erisir, Alev and Rudy, Bernardo }, citeulike-article-id = {2794345}, doi = {10.1016/j.neuron.2008.03.003}, journal = {Neuron}, keywords = {ais, axon, cortical\_neurons, electrophysiology, interneurons, kv}, month = {May}, number = {3}, pages = {387--400}, posted-at = {2008-05-13 13:22:45}, priority = {0}, title = {K+ Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons}, url = {http://dx.doi.org/10.1016/j.neuron.2008.03.003}, volume = {58}, year = {2008} }

TY - JOUR ID - citeulike:2794345 L3 - citeulike-article-id:2794345 TI - K+ Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons JF - Neuron VL - 58 IS - 3 SP - 387 EP - 400 N2 - Summary Fast-spiking cells (FS cells) are a prominent subtype of neocortical GABAergic interneurons with important functional roles. Multiple FS cell properties are coordinated for rapid response. Here, we describe an FS cell feature that serves to gate the powerful inhibition produced by FS cell activity. We show that FS cells in layer 2/3 barrel cortex possess a dampening mechanism mediated by Kv1.1-containing potassium channels localized to the axon initial segment. These channels powerfully regulate action potential threshold and allow FS cells to respond preferentially to large inputs that are fast enough to "outrun" Kv1 activation. In addition, Kv1.1 channel blockade converts the delay-type discharge pattern of FS cells to one of continuous fast spiking without influencing the high-frequency firing that defines FS cells. Thus, Kv1 channels provide a key counterbalance to the established rapid-response characteristics of FS cells, regulating excitability through a unique combination of electrophysiological properties and discrete subcellular localization. KW - ais KW - axon KW - cortical_neurons KW - electrophysiology KW - interneurons KW - kv AU - Goldberg, Ethan AU - Clark, Brian AU - Zagha, Edward AU - Nahmani, Mark AU - Erisir, Alev AU - Rudy, Bernardo PY - 2008/05/08/ UR - http://dx.doi.org/10.1016/j.neuron.2008.03.003 ER -