Mechanisms of voltage-gated ion channel regulation: from gene expression to localization.

@article{citeulike:2712150, abstract = {The ion channel milieu present in a neuron in large part determines the inherent excitability of a given cell and is responsible for the translation of sensory transduction and synaptic input to axonal output. Intrinsic excitability is a dynamic process subject to multiple levels of regulation from channel gene expression to post-translational modifications that influence channel activity. The goal of this review is to provide an overview of some of the mechanisms by which channels can be modified in order to influence neuronal output. We focus on four levels of regulation: channel gene transcription, alternative splicing of channel transcripts, post-translational modifications that alter channel kinetics (phosphorylation), and subcellular localization and trafficking of channel proteins.}, address = {Division of Biological Sciences, University of Missouri-Columbia, Columbia, 65211, Missouri, USA, SchulzD@missouri.edu.}, author = {Schulz, D J. and Temporal, S and Barry, D M. and Garcia, M L. }, citeulike-article-id = {2712150}, doi = {10.1007/s00018-008-8060-z}, issn = {1420-682X}, journal = {Cellular and molecular life sciences : CMLS}, keywords = {ion\_channels, nav, phosphorylation, review, trafficking}, month = {April}, posted-at = {2008-04-24 09:11:37}, priority = {0}, title = {Mechanisms of voltage-gated ion channel regulation: from gene expression to localization.}, url = {http://dx.doi.org/10.1007/s00018-008-8060-z}, year = {2008} }

TY - JOUR ID - citeulike:2712150 TI - Mechanisms of voltage-gated ion channel regulation: from gene expression to localization. JF - Cellular and molecular life sciences : CMLS AD - Division of Biological Sciences, University of Missouri-Columbia, Columbia, 65211, Missouri, USA, SchulzD@missouri.edu. SN - 1420-682X N2 - The ion channel milieu present in a neuron in large part determines the inherent excitability of a given cell and is responsible for the translation of sensory transduction and synaptic input to axonal output. Intrinsic excitability is a dynamic process subject to multiple levels of regulation from channel gene expression to post-translational modifications that influence channel activity. The goal of this review is to provide an overview of some of the mechanisms by which channels can be modified in order to influence neuronal output. We focus on four levels of regulation: channel gene transcription, alternative splicing of channel transcripts, post-translational modifications that alter channel kinetics (phosphorylation), and subcellular localization and trafficking of channel proteins. KW - ion_channels KW - nav KW - phosphorylation KW - review KW - trafficking AU - Schulz, D AU - Temporal, S AU - Barry, D AU - Garcia, M PY - 2008/04/14/ UR - http://dx.doi.org/10.1007/s00018-008-8060-z ER -