Heterogeneity of parvalbumin-containing neurons in the mouse main olfactory bulb, with special reference to short-axon cells and betaIV-spectrin positive dendritic segments.

@article{citeulike:2695738, abstract = {The structural features of parvalbumin-positive neurons were studied in the mouse main olfactory bulb (MOB). Parvalbumin-positive neurons were heterogeneous, including numerous medium-sized interneurons in the external plexiform layer (EPL), some few large short-axon cells and a few periglomerular cells. Their overall distribution pattern and structural features resembled those of the rat MOB. However, large short-axon cells were frequently encountered in the internal plexiform and granule cell layers, which were rare in the rat MOB. In addition a few large short-axon cells were also encountered throughout the EPL. These short-axon cells extended their axons mainly in the EPL, usually making columnar axonal fields. Most parvalbumin-positive cells except periglomerular cells were confirmed to be glutamic acid decarboxylase positive. We examined the immuno-localization of the markers for the axon initial segments (AISs), betaIV-spectrin and sodium channels, to determine whether or not heterogeneous parvalbumin-positive neurons have axons. We confirmed their localization on the AISs of the large short-axon cells and periglomerular cells. However, these markers were encountered on some patch-like segments on the dendritic processes instead of the thin axon-like processes of the medium-sized EPL interneurons. The present study revealed the diversity of parvalbumin-positive neurons in the mouse MOB and their particular structural properties hitherto unknown.}, address = {Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. kosaka@med.kyushu-u.ac.jp}, author = {Kosaka, T. and Kosaka, K. }, citeulike-article-id = {2695738}, comment = {mouse olfactory bulb parvalbumin positive neurons short dendritic segments positive for bIV spectrin and pan Nav}, doi = {10.1016/j.neures.2007.09.008}, issn = {0168-0102}, journal = {Neuroscience research}, keywords = {immuno, in\_vivo, nav, spectrin}, month = {January}, number = {1}, pages = {56--72}, posted-at = {2008-04-21 12:41:08}, priority = {0}, title = {Heterogeneity of parvalbumin-containing neurons in the mouse main olfactory bulb, with special reference to short-axon cells and betaIV-spectrin positive dendritic segments.}, url = {http://dx.doi.org/10.1016/j.neures.2007.09.008}, volume = {60}, year = {2008} }

TY - JOUR ID - citeulike:2695738 L3 - citeulike-article-id:2695738 TI - Heterogeneity of parvalbumin-containing neurons in the mouse main olfactory bulb, with special reference to short-axon cells and betaIV-spectrin positive dendritic segments. JF - Neuroscience research VL - 60 IS - 1 SP - 56 EP - 72 AD - Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. kosaka@med.kyushu-u.ac.jp SN - 0168-0102 N2 - The structural features of parvalbumin-positive neurons were studied in the mouse main olfactory bulb (MOB). Parvalbumin-positive neurons were heterogeneous, including numerous medium-sized interneurons in the external plexiform layer (EPL), some few large short-axon cells and a few periglomerular cells. Their overall distribution pattern and structural features resembled those of the rat MOB. However, large short-axon cells were frequently encountered in the internal plexiform and granule cell layers, which were rare in the rat MOB. In addition a few large short-axon cells were also encountered throughout the EPL. These short-axon cells extended their axons mainly in the EPL, usually making columnar axonal fields. Most parvalbumin-positive cells except periglomerular cells were confirmed to be glutamic acid decarboxylase positive. We examined the immuno-localization of the markers for the axon initial segments (AISs), betaIV-spectrin and sodium channels, to determine whether or not heterogeneous parvalbumin-positive neurons have axons. We confirmed their localization on the AISs of the large short-axon cells and periglomerular cells. However, these markers were encountered on some patch-like segments on the dendritic processes instead of the thin axon-like processes of the medium-sized EPL interneurons. The present study revealed the diversity of parvalbumin-positive neurons in the mouse MOB and their particular structural properties hitherto unknown. KW - immuno KW - in_vivo KW - nav KW - spectrin N1 - mouse olfactory bulb parvalbumin positive neurons short dendritic segments positive for bIV spectrin and pan Nav AU - Kosaka, T AU - Kosaka, K PY - 2008/01// UR - http://dx.doi.org/10.1016/j.neures.2007.09.008 ER -