Organization of ion channels in the myelinated nerve fiber.

by: SG Waxman, JM Ritchie

Science, Vol. 228, No. 4707. (28 June 1985), pp. 1502-1507.

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Abstract

The functional organization of the mammalian myelinated nerve fiber is complex and elegant. In contrast to nonmyelinated axons, whose membranes have a relatively uniform structure, the mammalian myelinated axon exhibits a high degree of regional specialization that extends to the location of voltage-dependent ion channels within the axon membrane. Sodium and potassium channels are segregated into complementary membrane domains, with a distribution reflecting that of the overlying Schwann or glial cells. This complexity of organization has important implications for physiology and pathophysiology, particularly with respect to the development of myelinated fibers.

@article{citeulike:2569886, abstract = {The functional organization of the mammalian myelinated nerve fiber is complex and elegant. In contrast to nonmyelinated axons, whose membranes have a relatively uniform structure, the mammalian myelinated axon exhibits a high degree of regional specialization that extends to the location of voltage-dependent ion channels within the axon membrane. Sodium and potassium channels are segregated into complementary membrane domains, with a distribution reflecting that of the overlying Schwann or glial cells. This complexity of organization has important implications for physiology and pathophysiology, particularly with respect to the development of myelinated fibers.}, author = {Waxman, S. G. and Ritchie, J. M. }, citeulike-article-id = {2569886}, issn = {0036-8075}, journal = {Science}, keywords = {axon, nav, nodes\_of\_ranvier}, month = {June}, number = {4707}, pages = {1502--1507}, posted-at = {2008-03-21 14:22:55}, priority = {0}, title = {Organization of ion channels in the myelinated nerve fiber.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/2409596}, volume = {228}, year = {1985} }

RIS record

TY - JOUR ID - citeulike:2569886 L3 - citeulike-article-id:2569886 TI - Organization of ion channels in the myelinated nerve fiber. JF - Science VL - 228 IS - 4707 SP - 1502 EP - 1507 SN - 0036-8075 N2 - The functional organization of the mammalian myelinated nerve fiber is complex and elegant. In contrast to nonmyelinated axons, whose membranes have a relatively uniform structure, the mammalian myelinated axon exhibits a high degree of regional specialization that extends to the location of voltage-dependent ion channels within the axon membrane. Sodium and potassium channels are segregated into complementary membrane domains, with a distribution reflecting that of the overlying Schwann or glial cells. This complexity of organization has important implications for physiology and pathophysiology, particularly with respect to the development of myelinated fibers. KW - axon KW - nav KW - nodes_of_ranvier AU - Waxman, SG AU - Ritchie, JM PY - 1985/06/28/ UR - http://view.ncbi.nlm.nih.gov/pubmed/2409596 ER -

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