Tracking the ends: a dynamic protein network controls the fate of microtubule tips

by: Anna Akhmanova, Michel O Steinmetz

Nature Reviews Molecular Cell Biology, Vol. 9, No. 4. (05 March 2008), pp. 309-322.

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Abstract

Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.

@article{citeulike:2568784, abstract = {Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks.}, author = {Akhmanova, Anna and Steinmetz, Michel O. }, citeulike-article-id = {2568784}, doi = {10.1038/nrm2369}, issn = {1471-0072}, journal = {Nature Reviews Molecular Cell Biology}, keywords = {cytosqueleton, eb1, microtubules, review, tips}, month = {March}, number = {4}, pages = {309--322}, posted-at = {2008-04-11 16:25:44}, priority = {0}, publisher = {Nature Publishing Group}, title = {Tracking the ends: a dynamic protein network controls the fate of microtubule tips}, url = {http://dx.doi.org/10.1038/nrm2369}, volume = {9}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2568784 L3 - citeulike-article-id:2568784 TI - Tracking the ends: a dynamic protein network controls the fate of microtubule tips JF - Nature Reviews Molecular Cell Biology VL - 9 IS - 4 SP - 309 EP - 322 PB - Nature Publishing Group SN - 1471-0072 N2 - Microtubule plus-end tracking proteins (+TIPs) are a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules. They form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities. +TIPs regulate different aspects of cell architecture by controlling microtubule dynamics, microtubule interactions with cellular structures and signalling factors, and the forces that are exerted on microtubule networks. KW - cytosqueleton KW - eb1 KW - microtubules KW - review KW - tips AU - Akhmanova, Anna AU - Steinmetz, Michel PY - 2008/03/05/ UR - http://dx.doi.org/10.1038/nrm2369 ER -

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