NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ.

@article{citeulike:2194017, abstract = {NF-kappaB signaling has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. However, the cellular and molecular activity of NF-kappaB signaling within the nervous system remains to be clearly defined. Here, we show that the NF-kappaB and IkappaB homologs Dorsal and Cactus surround postsynaptic glutamate receptor (GluR) clusters at the Drosophila NMJ. We then show that mutations in dorsal, cactus, and IRAK/pelle kinase specifically impair GluR levels, assayed immunohistochemically and electrophysiologically, without affecting NMJ growth, the size of the postsynaptic density, or homeostatic plasticity. Additional genetic experiments support the conclusion that cactus functions in concert with, rather than in opposition to, dorsal and pelle in this process. Finally, we provide evidence that Dorsal and Cactus act posttranscriptionally, outside the nucleus, to control GluR density. Based upon our data we speculate that Dorsal, Cactus, and Pelle could function together, locally at the postsynaptic density, to specify GluR levels.}, address = {Department of Biochemistry and Biophysics, Programs in Neuroscience and Cell Biology, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158-2822, USA.}, author = {Heckscher, E. S. and Fetter, R. D. and Marek, K. W. and Albin, S. D. and Davis, G. W. }, citeulike-article-id = {2194017}, comment = {Vertebrate homolog of wnt/wingless ? (other system that has nuclear and cytosqueletton effects)}, doi = {10.1016/j.neuron.2007.08.005}, issn = {0896-6273}, journal = {Neuron}, keywords = {drosophila, glur, nfkappab, surface\_expression}, month = {September}, number = {6}, pages = {859--873}, posted-at = {2008-01-04 09:54:34}, priority = {0}, title = {NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ.}, url = {http://dx.doi.org/10.1016/j.neuron.2007.08.005}, volume = {55}, year = {2007} }

TY - JOUR ID - citeulike:2194017 L3 - citeulike-article-id:2194017 TI - NF-kappaB, IkappaB, and IRAK control glutamate receptor density at the Drosophila NMJ. JF - Neuron VL - 55 IS - 6 SP - 859 EP - 873 AD - Department of Biochemistry and Biophysics, Programs in Neuroscience and Cell Biology, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158-2822, USA. SN - 0896-6273 N2 - NF-kappaB signaling has been implicated in neurodegenerative disease, epilepsy, and neuronal plasticity. However, the cellular and molecular activity of NF-kappaB signaling within the nervous system remains to be clearly defined. Here, we show that the NF-kappaB and IkappaB homologs Dorsal and Cactus surround postsynaptic glutamate receptor (GluR) clusters at the Drosophila NMJ. We then show that mutations in dorsal, cactus, and IRAK/pelle kinase specifically impair GluR levels, assayed immunohistochemically and electrophysiologically, without affecting NMJ growth, the size of the postsynaptic density, or homeostatic plasticity. Additional genetic experiments support the conclusion that cactus functions in concert with, rather than in opposition to, dorsal and pelle in this process. Finally, we provide evidence that Dorsal and Cactus act posttranscriptionally, outside the nucleus, to control GluR density. Based upon our data we speculate that Dorsal, Cactus, and Pelle could function together, locally at the postsynaptic density, to specify GluR levels. KW - drosophila KW - glur KW - nfkappab KW - surface_expression N1 - Vertebrate homolog of wnt/wingless ? (other system that has nuclear and cytosqueletton effects) AU - Heckscher, ES AU - Fetter, RD AU - Marek, KW AU - Albin, SD AU - Davis, GW PY - 2007/09/20/ UR - http://dx.doi.org/10.1016/j.neuron.2007.08.005 ER -