The debate on the kiss-and-run fusion at synapses

@article{citeulike:2135726, abstract = {It has long been proposed that following vesicle fusion, a small pore might open and close rapidly without full dilation. Such `kiss-and-run' vesicle fusion can in principle result in rapid vesicle recycling and influence the size and the kinetics of the resulting synaptic current. However, the existence of kiss-and-run remains highly controversial, as revealed by recent imaging and electrophysiological studies at several synapses, including hippocampal synapses, neuromuscular junctions and retinal bipolar synapses. Only a minor fraction of fusion events has been shown to be kiss-and-run, as determined using cell-attached capacitance recordings in endocrine cells, pituitary nerve terminals and calyx-type synapses. Further work is needed to determine whether kiss-and-run is a major mode of fusion and has a major role in controlling synaptic strength at synapses.}, author = {He, Liming and Wu, Ling-Gang }, citeulike-article-id = {2135726}, doi = {10.1016/j.tins.2007.06.012}, journal = {Trends in Neurosciences}, keywords = {membrane\_insertion, review, synapse, synaptic\_cycle}, month = {September}, number = {9}, pages = {447--455}, posted-at = {2008-02-25 16:15:29}, priority = {0}, title = {The debate on the kiss-and-run fusion at synapses}, url = {http://dx.doi.org/10.1016/j.tins.2007.06.012}, volume = {30}, year = {2007} }

TY - JOUR ID - citeulike:2135726 L3 - citeulike-article-id:2135726 TI - The debate on the kiss-and-run fusion at synapses JF - Trends in Neurosciences VL - 30 IS - 9 SP - 447 EP - 455 N2 - It has long been proposed that following vesicle fusion, a small pore might open and close rapidly without full dilation. Such `kiss-and-run' vesicle fusion can in principle result in rapid vesicle recycling and influence the size and the kinetics of the resulting synaptic current. However, the existence of kiss-and-run remains highly controversial, as revealed by recent imaging and electrophysiological studies at several synapses, including hippocampal synapses, neuromuscular junctions and retinal bipolar synapses. Only a minor fraction of fusion events has been shown to be kiss-and-run, as determined using cell-attached capacitance recordings in endocrine cells, pituitary nerve terminals and calyx-type synapses. Further work is needed to determine whether kiss-and-run is a major mode of fusion and has a major role in controlling synaptic strength at synapses. KW - membrane_insertion KW - review KW - synapse KW - synaptic_cycle AU - He, Liming AU - Wu, Ling-Gang PY - 2007/09// UR - http://dx.doi.org/10.1016/j.tins.2007.06.012 ER -