Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.

@article{citeulike:1890624, abstract = {Kinesin-5 is a homotetrameric motor protein that interacts with adjacent microtubules in the mitotic spindle. Kinesin-5 is also highly expressed in developing postmitotic neurons. Axons of cultured neurons experimentally depleted of kinesin-5 grow up to five times longer than controls and display more branches. The faster growth rates are accompanied by a doubling of the frequency of transport of short microtubules, suggesting a major role for kinesin-5 in the balance of motor-driven forces on the axonal microtubule array. Live-cell imaging reveals that the effects on axonal length of kinesin-5 depletion are caused partly by a lower propensity of the axon and newly forming branches to undergo bouts of retraction. Overexpression of wild-type kinesin-5, but not a rigor mutant of kinesin-5, has the inverse effect on axonal length. These results indicate that kinesin-5 imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array.}, address = {Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19104, USA.}, author = {Myers, K. A. and Baas, P. W. }, citeulike-article-id = {1890624}, doi = {10.1083/jcb.200702074}, issn = {0021-9525}, journal = {J Cell Biol}, keywords = {axon, axonal\_growth, microtubules, motor\_proteins}, month = {September}, number = {6}, pages = {1081--1091}, posted-at = {2008-04-01 11:05:45}, priority = {0}, title = {Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.}, url = {http://dx.doi.org/10.1083/jcb.200702074}, volume = {178}, year = {2007} }

TY - JOUR ID - citeulike:1890624 L3 - citeulike-article-id:1890624 TI - Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array. JF - J Cell Biol VL - 178 IS - 6 SP - 1081 EP - 1091 AD - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19104, USA. SN - 0021-9525 N2 - Kinesin-5 is a homotetrameric motor protein that interacts with adjacent microtubules in the mitotic spindle. Kinesin-5 is also highly expressed in developing postmitotic neurons. Axons of cultured neurons experimentally depleted of kinesin-5 grow up to five times longer than controls and display more branches. The faster growth rates are accompanied by a doubling of the frequency of transport of short microtubules, suggesting a major role for kinesin-5 in the balance of motor-driven forces on the axonal microtubule array. Live-cell imaging reveals that the effects on axonal length of kinesin-5 depletion are caused partly by a lower propensity of the axon and newly forming branches to undergo bouts of retraction. Overexpression of wild-type kinesin-5, but not a rigor mutant of kinesin-5, has the inverse effect on axonal length. These results indicate that kinesin-5 imposes restrictions on the growth of the axon and does so at least in part by generating forces on the axonal microtubule array. KW - axon KW - axonal_growth KW - microtubules KW - motor_proteins AU - Myers, KA AU - Baas, PW PY - 2007/09/10/ UR - http://dx.doi.org/10.1083/jcb.200702074 ER -