Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway

@article{citeulike:1588006, abstract = {Summary Little is known about how the distinct architectures of dendrites and axons are established. From a genetic screen, we isolated dendritic arbor reduction (dar) mutants with reduced dendritic arbors but normal axons of Drosophila neurons. We identified dar2, dar3, and dar6 genes as the homologs of Sec23, Sar1, and Rab1 of the secretory pathway. In both Drosophila and rodent neurons, defects in Sar1 expression preferentially affected dendritic growth, revealing evolutionarily conserved difference between dendritic and axonal development in the sensitivity to limiting membrane supply from the secretory pathway. Whereas limiting ER-to-Golgi transport resulted in decreased membrane supply from soma to dendrites, membrane supply to axons remained sustained. We also show that dendritic growth is contributed by Golgi outposts, which are found predominantly in dendrites. The distinct dependence between dendritic and axonal growth on the secretory pathway helps to establish different morphology of dendrites and axons.}, author = {Ye, Bing and Zhang, Ye and Song, Wei and Younger, Susan H. and Jan, Lily Y. and Jan, Yuh N. }, citeulike-article-id = {1588006}, comment = {Discusses distinction with Horton \& Ehlers 2005, need for a non dendrite-biased membrane traffic reporter (VSVG is more somatodendritic). ---=note-separator=--- Supplementary Figure 8 shows difference between dendrites and axon for endocytosis of dextran at 3 DIV in hippocampal neurons}, doi = {10.1016/j.cell.2007.06.032}, journal = {Cell}, keywords = {dendrites, drosophila, membrane\_insertion, neurites\_growth, re\_golgi}, month = {August}, number = {4}, pages = {717--729}, posted-at = {2007-08-27 10:43:41}, priority = {0}, title = {Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway}, url = {http://dx.doi.org/10.1016/j.cell.2007.06.032}, volume = {130}, year = {2007} }

TY - JOUR ID - citeulike:1588006 L3 - citeulike-article-id:1588006 TI - Growing Dendrites and Axons Differ in Their Reliance on the Secretory Pathway JF - Cell VL - 130 IS - 4 SP - 717 EP - 729 N2 - Summary Little is known about how the distinct architectures of dendrites and axons are established. From a genetic screen, we isolated dendritic arbor reduction (dar) mutants with reduced dendritic arbors but normal axons of Drosophila neurons. We identified dar2, dar3, and dar6 genes as the homologs of Sec23, Sar1, and Rab1 of the secretory pathway. In both Drosophila and rodent neurons, defects in Sar1 expression preferentially affected dendritic growth, revealing evolutionarily conserved difference between dendritic and axonal development in the sensitivity to limiting membrane supply from the secretory pathway. Whereas limiting ER-to-Golgi transport resulted in decreased membrane supply from soma to dendrites, membrane supply to axons remained sustained. We also show that dendritic growth is contributed by Golgi outposts, which are found predominantly in dendrites. The distinct dependence between dendritic and axonal growth on the secretory pathway helps to establish different morphology of dendrites and axons. KW - dendrites KW - drosophila KW - membrane_insertion KW - neurites_growth KW - re_golgi N1 - Discusses distinction with Horton & Ehlers 2005, need for a non dendrite-biased membrane traffic reporter (VSVG is more somatodendritic). N1 - Supplementary Figure 8 shows difference between dendrites and axon for endocytosis of dextran at 3 DIV in hippocampal neurons AU - Ye, Bing AU - Zhang, Ye AU - Song, Wei AU - Younger, Susan AU - Jan, Lily AU - Jan, Yuh PY - 2007/08/24/ UR - http://dx.doi.org/10.1016/j.cell.2007.06.032 ER -