DeTEKting ubiquitination of APC/C substrates.

by: AL Haas, KD Wilkinson

Cell, Vol. 133, No. 4. (16 May 2008), pp. 570-572.

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Abstract

Regulated protein degradation by the ubiquitin-proteasome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators required at earlier stages. The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome. Reporting in this issue, Jin et al. (2008) identify a TEK motif in both ubiquitin and substrates of APC/C that mediates assembly of these degradation signals.

@article{citeulike:2861024, abstract = {Regulated protein degradation by the ubiquitin-proteasome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators required at earlier stages. The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome. Reporting in this issue, Jin et al. (2008) identify a TEK motif in both ubiquitin and substrates of APC/C that mediates assembly of these degradation signals.}, address = {Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, New Orleans, LA 70112, USA.}, author = {Haas, A. L. and Wilkinson, K. D. }, citeulike-article-id = {2861024}, doi = {http://dx.doi.org/10.1016/j.cell.2008.04.034}, issn = {1097-4172}, journal = {Cell}, keywords = {apcc, cell, cycle, linear, motifs}, month = {May}, number = {4}, pages = {570--572}, posted-at = {2008-06-04 14:03:20}, priority = {0}, title = {DeTEKting ubiquitination of APC/C substrates.}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.034}, volume = {133}, year = {2008} }

RIS record

TY - JOUR ID - citeulike:2861024 L3 - citeulike-article-id:2861024 TI - DeTEKting ubiquitination of APC/C substrates. JF - Cell VL - 133 IS - 4 SP - 570 EP - 572 AD - Department of Biochemistry and Molecular Biology, Louisiana State University School of Medicine, New Orleans, LA 70112, USA. SN - 1097-4172 N2 - Regulated protein degradation by the ubiquitin-proteasome pathway ensures the unidirectionality of mitotic progression by removing cell-cycle regulators required at earlier stages. The APC/C ubiquitin-protein ligase targets proteins by appending polyubiquitin degradation signals that are subsequently recognized by the 26S proteasome. Reporting in this issue, Jin et al. (2008) identify a TEK motif in both ubiquitin and substrates of APC/C that mediates assembly of these degradation signals. KW - apcc KW - cell KW - cycle KW - linear KW - motifs AU - Haas, AL AU - Wilkinson, KD PY - 2008/05/16/ UR - http://dx.doi.org/10.1016/j.cell.2008.04.034 ER -

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