A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.

@article{citeulike:1570864, abstract = {The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer.}, address = {Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. tonks@cshl.edu}, author = {Tonks, N. K. and Muthuswamy, S. K. }, citeulike-article-id = {1570864}, doi = {http://dx.doi.org/10.1016/j.ccr.2007.02.022}, issn = {1535-6108}, journal = {Cancer Cell}, keywords = {inhibitor, phosphatase, review}, month = {March}, number = {3}, pages = {214--216}, posted-at = {2007-08-16 21:33:18}, priority = {2}, title = {A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.}, url = {http://dx.doi.org/10.1016/j.ccr.2007.02.022}, volume = {11}, year = {2007} }

TY - JOUR ID - citeulike:1570864 L3 - citeulike-article-id:1570864 TI - A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer. JF - Cancer Cell VL - 11 IS - 3 SP - 214 EP - 216 AD - Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. tonks@cshl.edu SN - 1535-6108 N2 - The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer. KW - inhibitor KW - phosphatase KW - review AU - Tonks, NK AU - Muthuswamy, SK PY - 2007/03// UR - http://dx.doi.org/10.1016/j.ccr.2007.02.022 ER -