Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?

@article{citeulike:1443008, abstract = {SummaryBackground Motor impairment resulting from chronic stroke can have extensive physical, psychological, financial, and social implications despite available neurorehabilitative treatments. Recent studies in animals showed that direct epidural stimulation of the primary motor cortex surrounding a small infarct in the lesioned hemisphere (M1lesioned hemisphere) elicits improvements in motor function.Recent developments In human beings, proof of principle studies from different laboratories showed that non-invasive transcranial magnetic stimulation and direct current stimulation that upregulate excitability within M1lesioned hemisphere or downregulate excitability in the intact hemisphere (M1intact hemisphere) results in improvement in motor function in patients with stroke. Possible mechanisms mediating these effects can include the correction of abnormally persistent interhemispheric inhibitory drive from M1intact hemisphere to M1lesioned hemisphere in the process of generation of voluntary movements by the paretic hand, a disorder correlated with the magnitude of impairment. In this paper we review these mechanistically oriented interventional approaches.What next? These findings suggest that transcranial magnetic stimulation and transcranial direct current stimulation could develop into useful adjuvant strategies in neurorehabilitation but have to be further assessed in multicentre clinical trials.}, author = {Hummel, Friedhelm C. and Cohen, Leonardo G. }, citeulike-article-id = {1443008}, journal = {The Lancet Neurology}, keywords = {medicine, neurology, stimulation, stroke, treatment}, month = {August}, number = {8}, pages = {708--712}, posted-at = {2007-07-08 17:49:54}, priority = {2}, title = {Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?}, url = {http://www.sciencedirect.com/science/article/B6X3F-4KF72B7-V/2/46db160c278939b13dc11c9117d4a590}, volume = {5}, year = {2006} }

TY - JOUR ID - citeulike:1443008 L3 - citeulike-article-id:1443008 TI - Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? JF - The Lancet Neurology VL - 5 IS - 8 SP - 708 EP - 712 N2 - SummaryBackground Motor impairment resulting from chronic stroke can have extensive physical, psychological, financial, and social implications despite available neurorehabilitative treatments. Recent studies in animals showed that direct epidural stimulation of the primary motor cortex surrounding a small infarct in the lesioned hemisphere (M1lesioned hemisphere) elicits improvements in motor function.Recent developments In human beings, proof of principle studies from different laboratories showed that non-invasive transcranial magnetic stimulation and direct current stimulation that upregulate excitability within M1lesioned hemisphere or downregulate excitability in the intact hemisphere (M1intact hemisphere) results in improvement in motor function in patients with stroke. Possible mechanisms mediating these effects can include the correction of abnormally persistent interhemispheric inhibitory drive from M1intact hemisphere to M1lesioned hemisphere in the process of generation of voluntary movements by the paretic hand, a disorder correlated with the magnitude of impairment. In this paper we review these mechanistically oriented interventional approaches.What next? These findings suggest that transcranial magnetic stimulation and transcranial direct current stimulation could develop into useful adjuvant strategies in neurorehabilitation but have to be further assessed in multicentre clinical trials. KW - medicine KW - neurology KW - stimulation KW - stroke KW - treatment AU - Hummel, Friedhelm AU - Cohen, Leonardo PY - 2006/08// UR - http://www.sciencedirect.com/science/article/B6X3F-4KF72B7-V/2/46db160c278939b13dc11c9117d4a590 ER -