Orbitofrontal Cortex and Its Contribution to Decision-Making.

@article{citeulike:1277499, abstract = {Damage to orbitofrontal cortex (OFC) produces an unusual pattern of deficits. Patients have intact cognitive abilities but are impaired in making everyday decisions. Here we review anatomical, neuropsychological, and neurophysiological evidence to determine the neuronal mechanisms that might underlie these impairments. We suggest that OFC plays a key role in processing reward: It integrates multiple sources of information regarding the reward outcome to derive a value signal. In effect, OFC calculates how rewarding a reward is. This value signal can then be held in working memory where it can be used by lateral prefrontal cortex to plan and organize behavior toward obtaining the outcome, and by medial prefrontal cortex to evaluate the overall action in terms of its success and the effort that was required. Thus, acting together, these prefrontal areas can ensure that our behavior is most efficiently directed towards satisfying our needs. Expected online publication date for the Annual Review of Neuroscience Volume 30 is June 16, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.}, address = {Helen Wills Neuroscience Institute and the Department of Psychology, University of California, Berkeley, CA 94720-3190 wallis@berkeley.edu.}, author = {Wallis, Jonathan D D. }, citeulike-article-id = {1277499}, doi = {10.1146/annurev.neuro.30.051606.094334}, issn = {0147-006X}, journal = {Annu Rev Neurosci}, keywords = {orbitofrontal, review}, month = {April}, posted-at = {2008-05-12 03:46:25}, priority = {2}, title = {Orbitofrontal Cortex and Its Contribution to Decision-Making.}, url = {http://dx.doi.org/10.1146/annurev.neuro.30.051606.094334}, year = {2007} }

TY - JOUR ID - citeulike:1277499 L3 - citeulike-article-id:1277499 TI - Orbitofrontal Cortex and Its Contribution to Decision-Making. JF - Annu Rev Neurosci AD - Helen Wills Neuroscience Institute and the Department of Psychology, University of California, Berkeley, CA 94720-3190 wallis@berkeley.edu. SN - 0147-006X N2 - Damage to orbitofrontal cortex (OFC) produces an unusual pattern of deficits. Patients have intact cognitive abilities but are impaired in making everyday decisions. Here we review anatomical, neuropsychological, and neurophysiological evidence to determine the neuronal mechanisms that might underlie these impairments. We suggest that OFC plays a key role in processing reward: It integrates multiple sources of information regarding the reward outcome to derive a value signal. In effect, OFC calculates how rewarding a reward is. This value signal can then be held in working memory where it can be used by lateral prefrontal cortex to plan and organize behavior toward obtaining the outcome, and by medial prefrontal cortex to evaluate the overall action in terms of its success and the effort that was required. Thus, acting together, these prefrontal areas can ensure that our behavior is most efficiently directed towards satisfying our needs. Expected online publication date for the Annual Review of Neuroscience Volume 30 is June 16, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. KW - orbitofrontal KW - review AU - Wallis, Jonathan D PY - 2007/04/06/ UR - http://dx.doi.org/10.1146/annurev.neuro.30.051606.094334 ER -