Damage to the Insula Disrupts Addiction to Cigarette Smoking

by: Nasir H Naqvi, David Rudrauf, Hanna Damasio, Antoine Bechara

Science, Vol. 315, No. 5811. (26 January 2007), pp. 531-534.

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Abstract

A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking. 10.1126/science.1135926

@article{citeulike:1069680, abstract = {A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking. 10.1126/science.1135926}, author = {Naqvi, Nasir H. and Rudrauf, David and Damasio, Hanna and Bechara, Antoine }, citeulike-article-id = {1069680}, doi = {http://dx.doi.org/10.1126/science.1135926}, journal = {Science}, keywords = {addiction, human, insula, lesion, smoking}, month = {January}, number = {5811}, pages = {531--534}, posted-at = {2007-01-26 19:47:00}, priority = {2}, title = {Damage to the Insula Disrupts Addiction to Cigarette Smoking}, url = {http://dx.doi.org/10.1126/science.1135926}, volume = {315}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1069680 L3 - citeulike-article-id:1069680 TI - Damage to the Insula Disrupts Addiction to Cigarette Smoking JF - Science VL - 315 IS - 5811 SP - 531 EP - 534 N2 - A number of brain systems have been implicated in addictive behavior, but none have yet been shown to be necessary for maintaining the addiction to cigarette smoking. We found that smokers with brain damage involving the insula, a region implicated in conscious urges, were more likely than smokers with brain damage not involving the insula to undergo a disruption of smoking addiction, characterized by the ability to quit smoking easily, immediately, without relapse, and without persistence of the urge to smoke. This result suggests that the insula is a critical neural substrate in the addiction to smoking. 10.1126/science.1135926 KW - addiction KW - human KW - insula KW - lesion KW - smoking AU - Naqvi, Nasir AU - Rudrauf, David AU - Damasio, Hanna AU - Bechara, Antoine PY - 2007/01/26/ UR - http://dx.doi.org/10.1126/science.1135926 ER -

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