Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells.

by: YC Smith, KK Grande, SB Rasmussen, AD O'Brien

Infection and immunity, Vol. 74, No. 1. (January 2006), pp. 750-757.

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Abstract

Human bladder 5637 cells cultivated under microgravity conditions formed organoids that displayed characteristics of in vivo tissue-specific differentiation. Uropathogenic Escherichia coli (UPEC) strain CP9 colonized and penetrated the organoids and induced alpha-hemolysin-mediated exfoliation of uroepithelial cells. We propose these uro-organoids as models that simulate the interactions between UPEC and terminally differentiated human urothelium.

@article{citeulike:3041655, abstract = {Human bladder 5637 cells cultivated under microgravity conditions formed organoids that displayed characteristics of in vivo tissue-specific differentiation. Uropathogenic Escherichia coli (UPEC) strain CP9 colonized and penetrated the organoids and induced alpha-hemolysin-mediated exfoliation of uroepithelial cells. We propose these uro-organoids as models that simulate the interactions between UPEC and terminally differentiated human urothelium.}, address = {Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Rm. B4052, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA.}, author = {Smith, Y. C. and Grande, K. K. and Rasmussen, S. B. and O'Brien, A. D. }, citeulike-article-id = {3041655}, doi = {http://dx.doi.org/10.1128/IAI.74.1.750-757.2006}, issn = {0019-9567}, journal = {Infection and immunity}, keywords = {bladder, infection, mature, organoid, upec, urothelium}, month = {January}, number = {1}, pages = {750--757}, posted-at = {2008-07-25 04:21:23}, priority = {2}, title = {Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells.}, url = {http://dx.doi.org/10.1128/IAI.74.1.750-757.2006}, volume = {74}, year = {2006} }

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TY - JOUR ID - citeulike:3041655 L3 - citeulike-article-id:3041655 TI - Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells. JF - Infection and immunity VL - 74 IS - 1 SP - 750 EP - 757 AD - Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Rm. B4052, 4301 Jones Bridge Rd., Bethesda, MD 20814-4799, USA. SN - 0019-9567 N2 - Human bladder 5637 cells cultivated under microgravity conditions formed organoids that displayed characteristics of in vivo tissue-specific differentiation. Uropathogenic Escherichia coli (UPEC) strain CP9 colonized and penetrated the organoids and induced alpha-hemolysin-mediated exfoliation of uroepithelial cells. We propose these uro-organoids as models that simulate the interactions between UPEC and terminally differentiated human urothelium. KW - bladder KW - infection KW - mature KW - organoid KW - upec KW - urothelium AU - Smith, YC AU - Grande, KK AU - Rasmussen, SB AU - O'Brien, AD PY - 2006/01// UR - http://dx.doi.org/10.1128/IAI.74.1.750-757.2006 ER -

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