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The role of cationic antimicrobial peptides in innate host defences

by: Robert E Hancock, Gill Diamond
Trends in Microbiology, Vol. 8, No. 9. (1 September 2000), pp. 402-410.


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Cationic antimicrobial peptides are found in all living species. A single animal can contain >24 different antimicrobial peptides, which fall into four structural classes. These peptides are produced in large quantities at sites of infection and/or inflammation and can have broad-spectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In addition, they interact directly with host cells to modulate the inflammatory process and innate defences.


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