Self-complementary oligopeptide matrices support mammalian cell attachment

@article{citeulike:2445315, abstract = {A new class of ionic self-complementary oligopeptides is described, two members of which have been designated RAD16 and EAK16. These oligopeptides consist of regular repeats of alternating ionic hydrophilic and hydrophobic amino acids and associate to form stable [beta]-sheet structures in water. The addition of buffers containing millimolar amounts of monovalent salts or the transfer of a peptide solution into physiological solutions results in the spontaneous assembly of the oligopeptides into a stable, macroscopic membranous matrix. The matrix is composed of ordered filaments which form porous enclosures. A variety of mammalian cell types are able to attach to both RAD16 and EAK16 membranous matrices. These matrices provide a novel experimental system for analysing mechanisms of in vitro cell attachment and may have applications in in vivo studies of tissue regeneration, tissue transplantation and wound healing.}, author = {Zhang, Shuguang and Holmes, Todd C. and Dipersio, Michael C. and Hynes, Richard O. and Su, Xing and Rich, Alexander }, citeulike-article-id = {2445315}, doi = {10.1016/0142-9612(95)96874-Y}, journal = {Biomaterials}, keywords = {positively, references}, month = {December}, number = {18}, pages = {1385--1393}, posted-at = {2008-02-28 21:56:03}, priority = {2}, title = {Self-complementary oligopeptide matrices support mammalian cell attachment}, url = {http://dx.doi.org/10.1016/0142-9612(95)96874-Y}, volume = {16}, year = {1995} }

TY - JOUR ID - citeulike:2445315 L3 - citeulike-article-id:2445315 TI - Self-complementary oligopeptide matrices support mammalian cell attachment JF - Biomaterials VL - 16 IS - 18 SP - 1385 EP - 1393 N2 - A new class of ionic self-complementary oligopeptides is described, two members of which have been designated RAD16 and EAK16. These oligopeptides consist of regular repeats of alternating ionic hydrophilic and hydrophobic amino acids and associate to form stable [beta]-sheet structures in water. The addition of buffers containing millimolar amounts of monovalent salts or the transfer of a peptide solution into physiological solutions results in the spontaneous assembly of the oligopeptides into a stable, macroscopic membranous matrix. The matrix is composed of ordered filaments which form porous enclosures. A variety of mammalian cell types are able to attach to both RAD16 and EAK16 membranous matrices. These matrices provide a novel experimental system for analysing mechanisms of in vitro cell attachment and may have applications in in vivo studies of tissue regeneration, tissue transplantation and wound healing. KW - positively KW - references AU - Zhang, Shuguang AU - Holmes, Todd AU - Dipersio, Michael AU - Hynes, Richard AU - Su, Xing AU - Rich, Alexander PY - 1995/12// UR - http://dx.doi.org/10.1016/0142-9612(95)96874-Y ER -