Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations.

@article{citeulike:797136, abstract = {Single-nucleotide polymorphisms (SNPs) may be extremely important for deciphering the impact of genetic variation on complex human diseases. The ultimate value of SNPs for linkage and association mapping studies depends in part on the distribution of SNP allele frequencies and intermarker linkage disequilibrium (LD) across populations. Limited information is available about these distributions on a genomewide scale, particularly for LD. Using 114 SNPs from 33 genes, we compared these distributions in five American populations (727 individuals) of African, European, Chinese, Hispanic, and Japanese descent. The allele frequencies were highly correlated across populations but differed by >20\% for at least one pair of populations in 35\% of SNPs. The correlation in LD was high for some pairs of populations but not for others (e.g., Chinese American or Japanese American vs. any other population). Regardless of population, average minor-allele frequencies were significantly higher for SNPs in noncoding regions (20\%-25\%) than for SNPs in coding regions (12\%-16\%). Interestingly, we found that intermarker LD may be strongest with pairs of SNPs in which both markers are nonconservative substitutions, compared to pairs of SNPs where at least one marker is a conservative substitution. These results suggest that population differences and marker location within the gene may be important factors in the selection of SNPs for use in the study of complex disease with linkage or association mapping methods.}, address = {Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44109-1998, USA. katrina@darwin.cwru.edu}, author = {Goddard, K. A. and Hopkins, P. J. and Hall, J. M. and Witte, J. S. }, citeulike-article-id = {797136}, doi = {http://dx.doi.org/10.1086/302727}, issn = {0002-9297}, journal = {Am J Hum Genet}, keywords = {snp}, month = {January}, number = {1}, pages = {216--234}, posted-at = {2008-07-15 13:09:05}, priority = {2}, title = {Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations.}, url = {http://dx.doi.org/10.1086/302727}, volume = {66}, year = {2000} }

TY - JOUR ID - citeulike:797136 L3 - citeulike-article-id:797136 TI - Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations. JF - Am J Hum Genet VL - 66 IS - 1 SP - 216 EP - 234 AD - Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44109-1998, USA. katrina@darwin.cwru.edu SN - 0002-9297 N2 - Single-nucleotide polymorphisms (SNPs) may be extremely important for deciphering the impact of genetic variation on complex human diseases. The ultimate value of SNPs for linkage and association mapping studies depends in part on the distribution of SNP allele frequencies and intermarker linkage disequilibrium (LD) across populations. Limited information is available about these distributions on a genomewide scale, particularly for LD. Using 114 SNPs from 33 genes, we compared these distributions in five American populations (727 individuals) of African, European, Chinese, Hispanic, and Japanese descent. The allele frequencies were highly correlated across populations but differed by >20% for at least one pair of populations in 35% of SNPs. The correlation in LD was high for some pairs of populations but not for others (e.g., Chinese American or Japanese American vs. any other population). Regardless of population, average minor-allele frequencies were significantly higher for SNPs in noncoding regions (20%-25%) than for SNPs in coding regions (12%-16%). Interestingly, we found that intermarker LD may be strongest with pairs of SNPs in which both markers are nonconservative substitutions, compared to pairs of SNPs where at least one marker is a conservative substitution. These results suggest that population differences and marker location within the gene may be important factors in the selection of SNPs for use in the study of complex disease with linkage or association mapping methods. KW - snp AU - Goddard, KA AU - Hopkins, PJ AU - Hall, JM AU - Witte, JS PY - 2000/01// UR - http://dx.doi.org/10.1086/302727 ER -