Population-based family studies in genetic epidemiology.

@article{citeulike:392683, abstract = {Designs that involve families (the traditional strength of genetic epidemiology) and population-based sampling (the traditional strength of environmental epidemiology) allow investigation of both genes and environment, separately or together, and allow valid inference to the population. These case-control-family designs (including those involving twin pairs), can be regarded as retrospective cohort studies of relatives, and can be used for: determining familial risks and genetic models; estimating risk (penetrance) for measured genotypes; genetic association studies; stratifying risks by family history and known mutation status; and studying modifiers of risk in genetically susceptible individuals. Follow-up of families allows genetic and environmental risks to be studied prospectively. We discuss statistical methods, theoretical and practical strengths, limitations, and other issues. Given their versatility, population-based family studies could become a principal framework in epidemiology, and move genetics from its traditional focus on high-risk families to give it a wider clinical and population health relevance.}, address = {University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, 723 Swanston Street, Carlton, Victoria 3053, Australia. j.hopper@unimelb.edu.au}, author = {Hopper, J. L. and Bishop, D. T. and Easton, D. F. }, citeulike-article-id = {392683}, doi = {10.1016/S0140-6736(05)67570-8}, issn = {1474-547X}, journal = {Lancet}, number = {9494}, pages = {1397--1406}, posted-at = {2007-11-07 02:13:21}, priority = {2}, title = {Population-based family studies in genetic epidemiology.}, url = {http://dx.doi.org/10.1016/S0140-6736(05)67570-8}, volume = {366}, year = {2005} }

TY - JOUR ID - citeulike:392683 L3 - citeulike-article-id:392683 TI - Population-based family studies in genetic epidemiology. JF - Lancet VL - 366 IS - 9494 SP - 1397 EP - 1406 AD - University of Melbourne, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, 723 Swanston Street, Carlton, Victoria 3053, Australia. j.hopper@unimelb.edu.au SN - 1474-547X N2 - Designs that involve families (the traditional strength of genetic epidemiology) and population-based sampling (the traditional strength of environmental epidemiology) allow investigation of both genes and environment, separately or together, and allow valid inference to the population. These case-control-family designs (including those involving twin pairs), can be regarded as retrospective cohort studies of relatives, and can be used for: determining familial risks and genetic models; estimating risk (penetrance) for measured genotypes; genetic association studies; stratifying risks by family history and known mutation status; and studying modifiers of risk in genetically susceptible individuals. Follow-up of families allows genetic and environmental risks to be studied prospectively. We discuss statistical methods, theoretical and practical strengths, limitations, and other issues. Given their versatility, population-based family studies could become a principal framework in epidemiology, and move genetics from its traditional focus on high-risk families to give it a wider clinical and population health relevance. AU - Hopper, JL AU - Bishop, DT AU - Easton, DF PY - 2005///1 UR - http://dx.doi.org/10.1016/S0140-6736(05)67570-8 ER -