Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis.

@article{citeulike:3005930, abstract = {OBJECTIVE: To quantitatively summarize the association between tumour necrosis factor alpha (TNF-alpha) gene polymorphisms and Graves' disease. DESIGN AND METHODS: Relevant studies were identified from the following electronic databases: Cochrane Library, MEDLINE, EMBASE and Chinese Bio-medicine Database. A meta-analysis of relevant studies was performed. RESULTS: This meta-analysis included 10 case-control studies, which included 2271 Graves' disease cases and 2633 controls. The combined results based on all studies showed that there was significant difference in genotype distribution (-308A/G; -308G/G; -863C/C; -863C/A; -1031C/T) between Graves' disease and controls. When stratifying for race, statistically significant results were observed in three genotype distribution (-863C/C; -863C/A; -1031C/T) between Graves' disease and controls among Asians. Statistically significant results were observed in only two genotype distribution (-308A/G; -308G/G) between Graves' disease and controls among Caucasians. CONCLUSIONS: This meta-analysis suggests that TNF-alpha gene polymorphisms at positions -308 (G-308A), -863 (C-863A), and -1031 (T-1031C) were associated with Graves' disease.}, address = {Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.}, author = {Li, N. and Zhou, Z. and Liu, X. and Liu, Y. and Zhang, J. and Du, L. and Wei, M. and Chen, X. }, citeulike-article-id = {3005930}, doi = {http://dx.doi.org/10.1016/j.clinbiochem.2008.04.014}, issn = {1873-2933}, journal = {Clinical biochemistry}, keywords = {china, meta-analysis, snp, tnf}, month = {July}, number = {10-11}, pages = {881--886}, posted-at = {2008-07-15 15:50:56}, priority = {2}, title = {Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis.}, url = {http://dx.doi.org/10.1016/j.clinbiochem.2008.04.014}, volume = {41}, year = {2008} }

TY - JOUR ID - citeulike:3005930 L3 - citeulike-article-id:3005930 TI - Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. JF - Clinical biochemistry VL - 41 IS - 10-11 SP - 881 EP - 886 AD - Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China. SN - 1873-2933 N2 - OBJECTIVE: To quantitatively summarize the association between tumour necrosis factor alpha (TNF-alpha) gene polymorphisms and Graves' disease. DESIGN AND METHODS: Relevant studies were identified from the following electronic databases: Cochrane Library, MEDLINE, EMBASE and Chinese Bio-medicine Database. A meta-analysis of relevant studies was performed. RESULTS: This meta-analysis included 10 case-control studies, which included 2271 Graves' disease cases and 2633 controls. The combined results based on all studies showed that there was significant difference in genotype distribution (-308A/G; -308G/G; -863C/C; -863C/A; -1031C/T) between Graves' disease and controls. When stratifying for race, statistically significant results were observed in three genotype distribution (-863C/C; -863C/A; -1031C/T) between Graves' disease and controls among Asians. Statistically significant results were observed in only two genotype distribution (-308A/G; -308G/G) between Graves' disease and controls among Caucasians. CONCLUSIONS: This meta-analysis suggests that TNF-alpha gene polymorphisms at positions -308 (G-308A), -863 (C-863A), and -1031 (T-1031C) were associated with Graves' disease. KW - china KW - meta-analysis KW - snp KW - tnf AU - Li, N AU - Zhou, Z AU - Liu, X AU - Liu, Y AU - Zhang, J AU - Du, L AU - Wei, M AU - Chen, X PY - 2008/07// UR - http://dx.doi.org/10.1016/j.clinbiochem.2008.04.014 ER -